204 results
Lu AF28996 is an orally administered investigational compound of a potent, long-acting dopamine agonist, Lu AA40326, currently under development by H. Lundbeck A/S for the treatment of Parkinson*s disease (PD). Primary Objective:to investigate the…
The objective of the study is to realize an efficient allocation of resources to the available treatment options in advanced PD, while guaranteeing the highest standard of care.Secondary objectives are 1) to quantify the need for and cost of…
This is a medical-scientific research study. The purpose of the study is to investigate the effect of multiple doses of the study compound BIA 28-6156 on the pharmacokinetics of the drugs levodopa-carbidopa (Group 1) and levodopa-benserazide (Group…
The primary objective of this study is to explore the potential efficacy of the Holocue application for alleviating FOG episodes through on-demand cue activation. In order to achieve this, walking data obtained from the Hololens will first be…
Overall aim: To examine the association between olfactory function, motor, and non-motor symptoms in a longitudinal cohort of PD patients.Specific objective(s): 1. To determine whether the degree of hyposmia in PD is associated with disease duration…
Primary objective:To investigate the pharmacokinetics (PK) of IZD174 in plasma and CSF of subjects with Parkinson*s Disease.Secondary objective:To investigate the pharmacodynamics (PD) of IZD174 in plasma of subjects with Parkinson*s Disease as…
Primary Objective: To determine different familial features (demographical, clinical, neurophysiological) in essential tremor families and subsequently clustering these features into subtypes of familial essential tremor. Secondary Objective(s): To…
1) to study the effects of 4 weeks of HIIT compared to 4 weeks of CAE on motor and non-motor aspects of PD; 2) to investigate the association between blood biomarkers for neuroplasticity / neurodegeneration and motor and non-motor performance for…
The main objective of this study is to identify cortical brain regions that show significant altered fNIRS activity during FOG in patients with PD. This is accomplished by considering four secondary objectives. First, we compare the cortical…
1. study the effects of an 8-week high-intensity interval training on motor and non-motor aspects (primary outcome: anxiety and depression) of Parkinson's disease and Multiple Sclerosis, compared to traditional continuous aerobic training and…
To compare the presence of freezing of gait in levodopa-naïve patients with Parkinson*s disease from Tanzania/Brazil with the presence of freezing of gait in Dutch Parkinson patients (matched for disease duration) who have received chronic pulsatile…
The main objective of the study is to evaluate the effect of BoNT-A injections on the intrinsic an reflexive contributions to ankle joint resistance for patients with spasticity. We hypothesize that, with respect to baseline, reflexive joint…
The main objectives of this study are to acquire EEG, ECG and motion data from 15 PD patients with FOG for the algorithm development to online detect and predict FOG, and test the performance of developed algorithm in 15 PD patients with FOG. We…
The main objective of this study is to predict the rate of decline for both motor and cognitive function in an existing PD patient cohort using a combination of baseline CSF and blood biomarker profiles (T0). The secondary objective is to determine…
The primary objective of this study is to assess the pharmacokinetics and the effect of food on the pharmacokinetics of the YTX-7739 tablet formulation following single oral doses of 30 mg in HVs and to compare the relative bioavailability of the…
The first objective is to validate novel digital biomarkers for disease progression in de novo Parkinson*s disease patients. The biomarkers can eventually serve as a primary clinical endpoint in additional future clinical studies. As part of this…
By following participants for two years we want to map out what changes are taking place in employed gene carriers of Huntington's disease. The research does not solely focus on whether a participant is employed or not, but wants to highlight…
The goal of this research is to assess whether cognitive effort (mental arithmetic) or fear (threat of shock) have a similar or different effect on Parkinson*s tremor and noradrenergic activity. In the following, obtained knowledge and empirical…
Primary objective: - To evaluate the effect of the STIL brace on tremor amplitude in patients with forearm tremor. Secondary objectives: - To evaluate the effect of the STIL brace on patients* impressions of tremor severity.- To assess patient…
To determine the presence and predictive value of MLE on cognition after DBS in PD.