204 results
Development of a cell transplantation therapy for PD through autologous stem cells.
Primary objective: To classify the effect of the pharmacogenetic profile of CYP2C19 and CYP2D6 in HD gene carriers, compared to more classic medication prescribing parameters (such as age and comorbidities) on negative medication effects of HD-…
Primary Objectives• Characterize day-to-day, within-day, intra-individual and inter-individual variability of GCase activity in healthy participants and patients with Parkinson*s disease with a GBA1 mutation.Secondary Objectives• Assess variability…
The main study objectives include to:a. Use clinical and biological data to estimate the mean rates of change and the variability around the mean of clinical, digital, imaging, biological and genetic outcomes in study participants.b. Confirm…
The goal of the current study is to evaluate both the feasibility and validity of the Corival ALT prototype for exercise testing in patients with lower limb deficits.
The general objective is to validate a new non-invasive retinal imaging tool that allows the identification of relevant biomarkers in the retina in degenerative diseases of the brain and the eye by scattering and absorption properties.
Primary Objective: To establish whether it is feasible to oppose slowness caused by gait impairments deriving from Parkinson*s disease effectively by using a tactile-based cueing device. Secondary Objective(s): To establish if the device influences…
The primary objective is to investigate the safety and tolerability of inhalation of glycopyrronium inhalation powder using different dosing regimens. The second objectives are to determine the decrease in drooling by using different dosing regimens…
The research question addressed in this study is:How do patients with advanced PD, their family caregivers and professionals their problems, needs and received care?This question will be explored by an examination of what patients, (former) family…
To characterize the following markers in a given subject across multiple times of day, and across multiple days, to gain an understanding of intra-subject variability.- GCase activity in PBMCs and in whole-blood,- GluCer in PBMCs and plasma-…
* Genotyping of the full GBA1 gene in people with Parkinson*s Disease, assessed as wildtype (GBA-) or containing a mutation (GBA+); the specific mutation will be recorded as well. * Assessing the presence of 7 known PD-causing mutations in the LRRK2…
To evaluate the validity of the peak frequency values and the amplitude at the peak frequency obtained from power spectral densities from the consumer product accelerometers and the laboratory-grade accelerometer following simultaneous tremor…
1. To study the differential effectiveness of three cueing modalities on gait parameters, gait stability, and interlimb coordination in people with Parkinson's disease 2. To study the differences between self-selected and a 10% increased cueing…
The primary objective is to investigate the cognitive effect of low-frequency stimulation of the nucleus basalis of Meynert (NBM) in advanced Parkinson*s disease (PD) patients, who were previously treated with deep brain stimulation (DBS) of the…
The primary objective of the study is to perform a set of hypothesis-driven analyses on the study data set, aiming to correlate established biomarkers (obtained clinically, from brain MRI, from CSF, from known genetic factors, and from monitoring of…
We aim to identify the circuit-level cerebral mechanisms underlying DT, and separate them from those involved in ET. Furthermore, we test whether a non-invasive intervention in this circuit (applied to the motor cortex or cerebellum) can…
The main goal of this study is to use individual pathophysiological characteristics (pattern of activity and connectivity within a patient*s tremor network; *tremor fingerprint*) to predict the effect of a new and non-invasive anti-tremor treatment…
1) Network patterns will be extracted from the FDG PET data images of 100 RBD participants. The key measure will be the expression of the PDRP pattern at the time of the clinical diagnosis RBD (polysomnographically confirmed). The basis for this…
The primary objective is to characterize the programming effects of Boston Scientific Vercise* PC System using the Deep Brain Stimulation Directional Lead for bilateral subthalamic nucleus DBS for the treatment of Parkinson*s disease in acute and…
a) Identification of stimulation site-specific functional and structural brain network characteristics in patients with PD and STN-DBS.b) Relating subject-specific stimulation sites and functional network changes to measures of cognitive and…