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Temporise or Terminate pregnancy in women with severe preeclampsia at 28-34 weeks.

To investigate the hypothesis that temporising treatment of women with early-onset, severe preeclampsia improves infant outcome and may reduce direct treatment costs in comparison to short-term planned delivery, while persistent maternal morbidity…

Towards Precision Medicine for Diabetes in Pregnancy

In the present study, we propose to investigate the efficacy of pharmacological treatment of GDM (using metformin) by the pathophysiological cause of hyperglycemia, namely reduced insulin sensitivity or reduced insulin secretion. Primary Objective:…

A Phase I/II, Open Label, Proof of Concept Study to investigate Tolerability and Safety of Treatment with Recombinant Human C1 Inhibitor (conestat alfa) in Patients with Preeclampsia.

Primary: To evaluate the tolerability and safety of the treatment with rhC1INH (conestat alfa) on top of Standard Care, for patients with pre-eclampsia.Secondary: To evaluate the efficacy of treatment with rhC1INH (conestat alfa) on top of Standard…

NIfedipine levels in Mothers with and without PreEclampsia and their Newborns.

Primary Objective: To compare the fetal/maternal ratio of nifedipine blood concentrations between pregnancies with and without hypertensive disorders, including preeclampsia.Secondary Objective: To compare predicted fetal/maternal drug ratios with…