65 results
With this research project we will investigate the relationship between SSRI concentration in the (pre)term neonate and clinical short and long term effects on the neonate after exposure to SSRI*s during pregnancy and lactation. Furthermore, the…
Cross-sectional study: To detect the normal range of amplitudes and segment intervals of the fECG. Case-cohort study: To compare the fECG between healthy fetuses and fetuses with various forms of severe CHD. To determine the diagnostic value of fECG…
To determine the feasibility of rs-fMRI in neonates undergoing a planned diagnostic MRI session following perinatal asphyxia. To assess intra-session reproducibility (test-retest reliability) of the rs-fMRI technique in neonates with asphyxia.
To obtain reference values of rsO2 of cerebral and muscle tissue measured by NIRO 200 NX for (relatively) healthy near term and term neonates.
To assess whether a higher prophylactic platelet transfusion threshold is superior to the lower thresholds in reducing the proportion of patients who experience a major bleed or death up to study day 28.
It is hypothesized that advanced hemodynamic monitoring will result in earlier detection of circulatory failure in critically ill newborn infants compared to clinical assessment of shock, which is the actual standard diagnostic tool in daily…
We aim to investigate the current practice of prenatal counseling amongst parents of extremely premature infants since the introduction of the new guideline in 2010. We will explore the contents and the practical aspects of the counseling.…
The aim of the current study is to get insight into the in potential lifelong consequences of active disease and or prednisone use during pregnancy on the children of women with rheumatoid arthritis. As readout it uses indicators (risk factors) for…
First objective: To assess late neonatal neurological outcome in infants with duct dependent CHD and to gain more insight into the timing of brain damage. We will determine whether the quality of GMs at an age of seven days and three months is…
The aim of the study is to gain more insight in the course of intestinal oxygenation, urinary I-FABP concentration, and plasma Citrulline levels (as markers for intestinal damage and recovery) after NEC in relation to time to full enteral feeding…
The aim of the trial is to obtain data on the optimal dose, feasibility and pharmacokinetics of bumetanide when given as an add-on treatment for seizures in full term babies with hypoxic ischemic encephalopathy (HIE). Bumetanide will be given in a…
To establish normal ranges for the lateral ventricles in neonates with a gestational age ranging from 25 to 42 weeks.
The development of a disease specific questionnaire to measure the quality of life in children with BPD at age 4-8, that can be answered by the parents.
To evaluate the course of concentrations of oxidative stress parameters and neuro-biomarkers in cord blood, serum and urine of full-term asphyxiated neonates. Furthermore, to investigate whether these concentrations are correlated to hypoxic…
A:To get insight whether respiratory support in the neonatal population, as artificially ventilation and Nasal Continously Positive Airway Pressure, will give an increased stress or pain respons which only can be detected by a 24 hours SCA…
The ultimate goal of this research is the clinical implementation of a non-invasive test for prenatal fetal genotyping, including fetal sex determination, using cff DNA in maternal plasma, to replace the current standard practice of invasive tests,…
Primary objective: to study the pharmacokinetics and pharmacodynamics of paracetamol intravenously in preterm infants with a gestational age of less than 32 weeks:Secondary objective(s): to study the safety and dose-effect relationship of…
Is it feasible to measure mean systemic filling pressure (Pmsf) and ΔetCO2 secondary to an incubator tilt maneuver in newborn infants?
1) To test the feasibility of vaccinating pregnant women against B. pertussis in preventing B. pertussis infection in newborn babies.2) To test the safety of vaccinating pregnant women against B. pertussis in preventing B. pertussis infection in…
In this study we want to determine the most adequate parameters (clinical, echocardiographic, Near Infrared Spectroscopy (NIRS) and B-type Natriuretic Peptide (BNP)) to diagnose a hemodynamic significant PDA. A second objective is to gather normal…