Search for a trial

The Impact of Psychological and Medical Factors of Women having a Child with a Congenital Anatomical Malformation on Subsequent Pregnancy Decision-Making: a psychological evaluation.

To identify factors that have an influence on the reproductive decision-making for a subsequent pregnancy of women having a child with congential anatomical anomalies.

The Eindhoven Breech Intervention Study (EBIS)

Primary outcome is to evaluate whether successful ECV is associated with maternal thyroid function and mood state in single pregnant women with breech position at end term.

Correlation and level of agreement between echocardiography and a new inert gas rebreathing technique in estimating cardiac output

We would like to perform a study in which first the level of agreement and the correlation between echocardiography and the new rebreathing technique in estimating cardiac output will be determined.

Determinants of Obstetric Outcome: a longitudinal study

Aim of this study is to identify how pregnancy complications can be predicted from the interplay between psychological, social and somatic risk factors. We hypothesize that the personality trait neuroticism predisposes to complications of pregnancy…

The prevalence of postpartum posttraumatic stress symptoms, depression, anxiety and the need of control in women delivered in The Netherlands

To assess the prevalence of postpartum posttraumatic stress symptoms, depression, anxiety and the need of control in women delivered in The netherlands.

Prostaglandins or balloon for induction of labour at term

To assess in term pregnant women with an unfavourable cervix (Bishop score < 6, Appendix1) the effectiveness of induction of labour with a transcervical Foley catheter as compared to induction with prostaglandins.

Pregnancy and Infant Development Study

The primary objective of the PRIDE Study is to identify factors to which a woman is exposed during her pregnancy that have an influence on the health status of the mother and/or her (unborn) child. In addition, the evaluation of preconception,…

Neonatal C-peptide concentration in urine: is it related to birthweight and glucose values on the first day of life or parameters of carbohydrate metabolism in non-diabetic mothers

to determine the correlation of fetal hyperinsulinemia (measured by urine c-peptide) and maternal indicators of glucose-regulation with neonatal birth weight and postpartum glucose concentration of macrosomic infants of non-diabetic mothers

Advanced prenatal screening in the first trimester of pregnancy:
ADAM12 and PP13 as new screening markers for aneuploidy and adverse pregnancy outcome.

The RIVM, UMCU and VUmc collectively will perform a prospective study in which the screening value of ADAM12 and PP13 for chromosomal abnormalities and adverse pregnancy outcome will be investigated.

An observational study to determine the association between stress urinary incontinence and levator avulsions

To investigate the association of anatomical defects with the occurrence of stress urinary incontinence.

Which factors before and during pregnancy can predict the severity of labourpain? A observational prospective cohort study in women and their partners to the pain threshold before and during pregnancy, constitution, inflammatory status and the relationship with and the character of the partner.

The primary objective is to examine whether the pain threshold during pregnancy is associated with the intensity of the pain and whether there is difference between before and during pregnancy. In addition, we examine associations between (pro)…

Predictors for chronification of pregnancy related pelvic girdle pain.

To identify the factors who are responsible for the chronification of pregnancy related pelvic girdle pain.

SCAR study
Sonohysterographic evaluation of caesarean scar defects and determination of risk factors

Determination of the incidence of a scar defect .Determination of riskfactors for develpment of scar defects

The Generation R Study, Phase 3 - Focus at 9

The general aim of the Generation R Study is to examine environmental and genetic causes that influence growth, development and health during fetal life, childhood and adulthood.The more specific aims of the study are: (1) To describe normal and…

HAPPY-follow: Longitudinal follow-up of mothers and children of the HAPPY study (Holistic Approach to Pregnancy and first Postpartum Year)

The primary objectives :Are children of mothers with sub-optimal thyroid function and/or sub-clinical hypothyroidism and/or hypothyroxinemia during early pregnancy at risk for developmental delay at the age of two and does this possible delay…

An open-label, two-way cross-over, randomized study to assess the pharmacokinetics and safety/tolerability of intra-vaginal delivery of gonadorelin and oxybutynin in healthy female volunteers

1. To explore the pharmacokinetics (PK) of intra-vaginal delivery of gonadorelin and oxybutynin. 2. To assess the safety and tolerability of gonadorelin and oxybutynin delivery with a prototype intra-vaginal ring.

A lifestyle intervention to reduce gestational weight gain and smoking in pregnant women to prevent perinatal morbidity

The overall aim is to study the effects of a lifestyle intervention for young women who are pregnant <= 12 weeks of gestational age and have a high risk on perinatal morbidity because of prepregnancy overweight or obesity and, if applicable,…

Functional cardiac adaptation during and after pregnancy

The aim of this study is to determine functional parameters of the maternal heart during the lactation period by echocardiography and to correlate these functional parameters with circulating hormones.

Comparison of Point-Of-Care Testing and venous blood glucose samples at the oral glucose tolerance test in pregnancy: a prospective observational cohort study

To assess the utility and diagnostic accuracy of capillary glucose samples (using the Roche Accu-Chek Inform II point-of-care testing device) compared with venous glucose samples with laboratory determination as the gold standard. To determine the…

Screening gestational diabetes: glucose curve versus oral glucose tolerance test

The primary objective is to compare the glucose curve with the OGTT, as a screening test for GDM.The secondary objective is to see if GDM treated after screening either with the glucose curve or with the OGTT, can predict perinatal complications and…