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Once-daily oral direct factor Xa rivaroxaban in the long-term prevention of recurrent symptomatic venous thromboembolism in patients with symptomatic deep-vein thrombosis or pulmonary embolism. The Einstein-Extension study.

The purpose of this study is to show that the incidence of new thrombotic events during an additional 6 or 12 months of treatment with rivaroxaban is lower when compared to placebo and that the likely advantage of an extended effect is not offset by…

Clopidogrel for the prevention of late cardiac events in patients with asymptomatic perioperative acute coronary syndrome.

The primary objective of this study is to determine whether clopidogrel + best medical treatment is superior to best medical treatment only in preventing:A) cardiovascular death, MI, stroke, or severe ischemia of the coronary or peripheral arterial…

Organ protection by noble gases * Helium induced Early and Late Preconditioning (HELP) in human endothelium

The aim of this clinical study is to investigate whether the non-anaesthetic noble gas helium induces EPC and LPC of human endothelium in vivo.

The incidence of endothelial dysfunction and atherogenesis in hemophilia patients with obesity: the Idaho-study

Are overweight or obese patients protected against atherosclerosis when suffering from haemophilia A? Is this association influenced by the severity of haemophilia? When the coagulation activity increases due to obesity (and inflammation), will this…

A phase 3, randomized, double-blind, active controlled (enoxaparin 40 mg QD), parallel-group, multi-center study to evaluate the safety and efficacy of Apixban in subjects ondergoing elective total knee replacement surgery.

To demonstrate that oral apixaban 2.5 mg BID is superior to subcutaneous (SC)enoxaparin 40 mg QD in reducing the event rate on the composite endpoint of adjudicated asymptomatic and symptomatic DVT, non-fatal PE and all-cause death through Day 12 of…

The Real-World Endeavor Resolute versus Xience V Drug-Eluting Stent Study in Twente

Primary research questions:* To investigate whether the clinical outcome following the randomized implantation of the Endeavor Resolute® versus XIENCE V® drug-eluting stent is similar, as assessed in a non-inferiority setting by comparing target-…

Stenting of Haemodialysis Acces Trial

To demonstrate the efficacy of a PTFE covered stent-graft in the prevention of outflow re-stenosis in loop fistula in a prospective trial.

Effects of Temporary Inhibition of the Renin-Angiotensin System on future blood pressure and hypertensive organ damage in young prehypertensive adults * TIResiAS

To test the hypothesis whether treatment with an ACE inhibitor in young prehypertensive adults reduces blood pressure 2 years after cessation of active treatment and to determine whether this treatment can reduce left ventricular mass and…

SPRING-study: Efficacy of paramedical use of software-guided cardiovascular prevention programs in a first-line general practitioner setting, comparison of care provided via telemonitoring or within general practice setting.

Which is the best way for cardiovascular prevention according to the Dutch general practitioner's guidelines, in a general pratitioner's office?a. By a nurse practioner, supervised by the general practitioner, while the frequency and…

Excercise induced circulatory improvement in formerly preeclamptic women

To test the hypothesis that in formerly preeclamptic women with a low plasma volume a month physical excercise improves vascular and hemodynamic functions.

Cardiovascular and metabolic health after the challenge of pregnancy: development and evaluation of a strategy of individual health risk appraisal and tailored intervention

1. To develop a postpartum strategy of appraisel of cardiovascular and metabolic health after pregnancies, complicated by PE, IUGR or GD.2. To develop and evaluate the feasibility of a lifestyle intervention strategy.3. To design a study proposal…

Medically Ill Patient Assessment of Rivaroxaban Versus Placebo IN Reducing Post-Discharge Venous Thrombo-Embolism Risk (MARINER)

Primary ObjectiveThe primary objective is to assess the efficacy and safety of rivaroxaban compared with placebo in the prevention of symptomatic venous thromboembolism (VTE) and VTE-related death posthospital discharge in high-risk, medically ill…

Implementation of Cardiovascular Risk management for patients with Rheumatoïd Arthritis (I-CaRe)

The main aim of this implementation research is to systematically screen all RA patients of Reade rheumatology and revalidation centre in Amsterdam for their cardiovascular risk profile and if necessary to treat them for cardiovascular risk factors…

Reduced-dosed rivaroxaban and standard-dosed rivaroxaban versus ASA in the long-term prevention of recurrent symptomatic venous thromboembolism in patients with symptomatic deep-vein thrombosis and/or pulmonary embolism
The Einstein Choice Study

1. The primary efficacy objective is to evaluate whether rivaroxaban, in doses of 10 mg or 20 mg, is superior to ASA 100 mg in the prevention of the primary efficacy outcome (i.e. fatal or non-fatal symptomatic recurrent venous thromboembolism).2.…

Anticoagulant treatment after knee arthroscopy or during plaster cast lower leg immobilisation: determining the balance between benefits and risks

Comparative effectiveness research to determine cost-effectiveness of an existing healthcare policy, i.e. treatment with low molecular weight heparin (LMWH) after knee arthroscopy and lower leg plaster cast immobilization following surgical or…

Fifteen years of statin therapy started in childhood: efficacy, safety, compliance and tolerability in patients with familial hypercholesterolemia

The aim of this study is to evaluate the efficacy, safety, compliance and tolerability of 15 years of pravastatin therapy initiated during childhood in young adult FH patients.

*Cost-effectiveness of tailoring anticoagulant therapy by a VTE recurrence prediction model in patients with venous thrombo-embolism as compared to care-as-usual: the VISTA study.*

OBJECTIVESThe objective is to quantify the cost-effectiveness and efficacy of formally applying the guideline evaluating the risk-benefit ratio of the duration of anticoagulant therapy (VKA treatment) by a previously developed VTE recurrence…

Curcumin study: Plasma concentrations of curcumin, piperin and genistein in subjects using over the counter supplements

The aim of this study is to investigate if curcumin is detectable when subjects use curcumin supplements in daily life.

Five year follow up of duplex investigations in young patients with a history of suspect venous disorders

Follow up of 38 patients who had a duplex investigation in the past when they were 18 years old or younger.

Biomarkers of microvascular function, circulating cells and endothelial integrity in kidney transplant recipients on belatacept or CNI

To disclose the pathofysiologic basis of the favourable risk profile by measuring factors associated with cardiovascular disease.