36 results
With a standardized approach in a population with difficult to treat hypertension we want to explore how frequenty PHA is a cause of hypertension and what the test characteristics of the aldosterone-renin ratio are. Additionally we want to…
In this trial, current usual care concerning cardiovascular education is described. Second aim is to study what is understood of this education by the patient. Last aim is to study what effect training of GP's on this subject will have on the…
The goal of this study is examining the acute effects of insulin on microcirculation in hypertensive insulinresistant subjects and investigate if angiotensine II influences these effects. Amendement: The goal of the amendement is to exame the…
The primary objective of the study is to evaluate the efficacy of aliskiren, valsartan and a combination of both drugs versus placebo in lowering levels of NT-proBNP in stabilized patients post ACS
A randomized comparative study of the treatment of the insufficient greater saphenous vein: crossectomy with short strip vs Ultrasound guided foam sclerosis vs endovasculair laser. The Magna trial. The emphasis of this study will be on comparing the…
The primary objective is identification of a set of genes as candidate monocyte markers for acute coronary complications and subsequent identification of a prognosis classifier to discriminate vulnerable, stable, and control subjects, based on the…
1. to investigate whether the known chronic inflammatory and hyperoxidative state in patients with severely increased LDL is associated with dysfunctional HDL.2. to investigate whether CVD in FH is associated with dysfunctional HDL.
The purpose of this study is to gain insight into the effects of auditory pacing on the stability and flexibility of hemiplegic gait coordination. It will be examined how auditory pacing can be best administered to improve the quality of hemiplegic…
Our aim is to evaluate the patency of cryoplasty in patients with intermittent claudication or critical ischemia, where exercise training is ineffective. Furthermore, we will evaluate whether cryoplasty will significantly improve the quality of life…
The aim of this study is to investigate the safety of treatment of PE in an outpatient setting based on normal pro-BNP levels. The mortality rate and the incidence of hemodynamic instability as well as major bleeding and recurrent VTE in the…
To study the feasiblity of cardiac MRI at 3T and the potential benefits of the intravascular contrast agent gadofosveset for studying and quantifiaction of heart function and -perfusion.
To investigate whether COX-2 inhibition enhances platelet aggregation by suppression of prostacyclin formation without suppressing thromboxane formation
The purpose of this project is to explore the interaction between caffeine and dipyridamole on ischemia-reperfusion injury in the forearm.
The purpose of this study is to show that the incidence of new thrombotic events during an additional 6 or 12 months of treatment with rivaroxaban is lower when compared to placebo and that the likely advantage of an extended effect is not offset by…
To assess the influence of bloodpressure, wall thickness, wall properties, and geometry changes throughout the cardiac cycle on the wall stress calculations. Previous analysis were performed with an assumed bloodpressure value, an uniform wall…
1) To determine the prevalence of MetS in the patient population of the MMIJ in IJsselstein aged 20 to 70 years2) To assess the effectiveness of population screening for MetS by general practitioners in a medium-size city in the Netherlands
In this study we will test the study hypothesis whether there is differential gene expression between patients with a history of premature MI and healthy controls when testing RNA obtained from highly purified platelets and monocytes.
Aim of this study is to quantify the relationship between the extent of aortic atherosclerotic disease and neurocognitive dysfunction after cardiac surgery with the use of cardiopulmonary bypass.
The aim of the proposed study will determine new duplex ultrasound velocity (DUS) criteria for reference/normal values and in-stent re-stenosis after aorto-iliac stenting.
In this study the differences in variability and stability of people walking with and without a limb prosthesis will be investigated. In addition, it will be studied which of the employed outcome measures will discriminate best between both groups.…