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An open-label, randomized, single center, crossover study in healthy participants to assess lipoprotein lipase activity and levels, and triglyceride levels after heparin exposure, in both fasted and postprandial state

In this study we will investigate biomarkers in blood after exposure to heparin in the fasted state or after a high-fat meal. Biomarkers are proteins present in the blood. The biomarkers investigated in this study are proteins that are involved in…

Prospective, Multicenter, Post-market, Single Arm study to confirmthe performance of the RenzanTM Peripheral Stent System in treating Superficial Femoral and/or Popliteal artery disease

Primary objective: To confirm the safety and efficacy of the RenzanTM Peripheral Stent System when used for treatment of superficial femoral (SFA) and/or popliteal (POP) artery disease.Secondary objective: Assessment of the primary patency of the…

Autonomic function in Alzheimer: assessment using tilt-table testing

The primary objective is to determine if there is a difference in autonomic function between patients with Alzheimer*s disease (MCI and AD) and a matched control group. The secondary objectives will be explorative and aimed to investigate…

Unruptured Cerebral Aneurysm: prediction of evolution: a prospective multi-centre study

Our primary aim is to evaluate in clinical practice the predictive value of unruptured intracranial aneurysm wall enhancement for aneurysm growth. It will allow to set up a secure, efficient and personalized follow-up.

Computational Fluid Dynamics for estimating the Pressure Gradient of Serial Stenotic Lesions

To determine the accuracy of computational fluid dynamic models for the quantification of the pressure gradient of tandem stenoses in the femoropopliteal artery, as compared to invasive pressure measurements.

Microvascular and Cardiovascular Status of Females with and without Migraine

The primary objective is to determine and compare the microvascular status between middle-aged women with and without migraine. Secondary objectives include a determination of the agreement and reproducibility of two devices which measure the blood…

The influence of antiphospholipid antibodies on INR values measured with the CoaguChek XS

The primary goal of this study is to determine discrepancies between INR measurements with Coaguchek XS and Coagulometer in APS patients. The secondary objective is to investigate which antiphospholipid antibodies correlate with the observed INR…

VenaSeal Spectrum: Global, Post-Market, Prospective, Multi-Center, Randomized Controlled Trial of the VenaSeal* Closure System vs. Surgical Stripping or Endothermal Ablation (ETA) for the Treatment of Early and Advanced Stage Superficial Venous Disease.

Randomized Studies (CEAP 2-5): To evaluate the patient*s experience and clinical improvement after treatment with the VenaSeal* system compared to standard of care treatments, surgical stripping or ETA, in the treatment of symptomatic superficial…

Vascular Phenotypes in a Geriatric Population

The objective of this study is to relate different vascular phenotypes, based on macro- and microvascular measurements, to changes in cognitive and physical functioning in a geriatric population.

A Randomised, Parallel, Double-Blind, Placebo-Controlled Phase 2b Study to Assess the Safety, Tolerability and Efficacy of AZD8233 Treatment in Participants with Hyperlipidaemia (SOLANO)

To assess the safety and tolerability of AZD8233 as compared with placebo in participants with hyperlipidaemia receiving maximally tolerated statin and/or ezetimibe therapy as defined by the investigator.

Detecting mitochondrial oxygen tension (mitoPO2) as a measure of local tissue oxygenation in patients with various stages of PAD with the Cellular Oxygen Metabolism (COMET) measurement system of Photonics Healthcare B.V. - A pilot study

This is a pilot study to assess the feasibility and tolerability of mitochondrial oxygenation measurements in patients with moderate to severe claudication (Rutherford class 4-6) with the COMET device in combination with Alacare. As secondary aims…

A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study to Compare the Efficacy and Safety of Sotatercept Versus Placebo When Added to Background Pulmonary Arterial Hypertension (PAH) Therapy for the Treatment of PAH

The objective of this study is to evaluate the efficacy and safety of sotatercept treatment (plus background PAH therapy) versus placebo (plus background PAH therapy) at 24 weeks in adults with PAH.

A prospective cohort study evaluating the occurrence of short and long-term cardiovascular complications in patients hospitalized with COVID-19

To determine the occurrence and natural history of (subclinical) cardiac abnormalities during hospital admission for COVID-19 and the possible cardiovascular complications short-tem (6 months) and long-term (1,2,5,10 years) post-admission.

Feasibility of ultrasound particle image velocimetry to quantify flow in the abdominal aorta before and after endovascular aneurysm repair

The aim of this study is to determine the feasibility of ultrafast contrast-enhanced ultrasound particle image velocimetry (echoPIV) measurements to quantify spatiotemporal blood flow velocity profiles in the abdominal aorta of AAA patients before…

Transdermal Rigidity assessment via Ischemia (and temperature) of the Penis (TRIP) versus the Rigiscan. A new sensor-driven device to measure rigidity of the penis.

In men without erectile problems, night time erections occur during the REM-sleep. For this study we will compare the current diagnostic test, the Rigiscan, with the data from de TRIP-Patch during the night. To validate discriminating sensor-…

Tailoring P2Y12 Inhibiting Therapy in Patients requiring Oral Anticoagulation after undergoing Percutaneous Coronary Intervention: The Switching Anti-Platelet and Anti-Coagulant Therapy - 2 Study

The aim of this study is to assess the pharmacodynamic effects of different P2Y12 inhibiting therapy (clopdiogrel vs ticagrelor) in patients at high risk for HPR identified according to the ABCD-GENE score in PCI treated patients also requiring OAC…

Ultrafast ultrasonic COMpound Push wave imAging and Strain eStimation (Ultra-COMPASS) for individual plaque stratification in the carotid arteries

Investigate whether it is possible to detect plaque stabilization, determined by plaque stiffness, after a stroke or TIA with Ultra-COMPASS ultrasound measurements.

Physician-Initiated PMCF Trial Investigating the Solaris Vascular Stent Graft for the treatment of iliac lesions - SOLARIS Peripheral PMCF Trial

The objective of this clinical investigation is to evaluate, in a controlled setting, the long-term (up to 12 months) safety and efficacy of the Solaris Vascular Stent Graft (Scitech) in clinical settingswhen used according to the indications of the…

Multi-centre, randomised, open-label, blinded endpoint assessed, trial of corticosteroids plus intravenous immunoglobulin (IVIG) and asperin, versus IVIG and asperin for prevention of coronary artery aneurysm (CAA) in Kawasaki disease (KD)

The overarching goal is to optimise the treatment of KD in children/adolescents across Europe.KD-CAAP will test the hypothesis that adding immediate adjunctive corticosteroid treatment to IVIGand aspirin will reduce CAA rates in unselected KD…

Genotype-guided strategy for antithrombotic treatment versus conventional clopidogrel therapy in peripheral arterial disease.

This study has been transitioned to CTIS with ID 2024-518122-33-00 check the CTIS register for the current data. The primary aim of the GENPAD study is to evaluate the ability of genotype-guided antithrombotic treatment to reduce adverse clinical…