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A Two-Part, Open-Label, Randomized, Placebo-Controlled, Crossover Study to Assess the Reversal of the Anticoagulant Effects of milvexian by 4-Factor Prothrombin Complex Concentrate (4F-PCC) (Part 1) and Recombinant Human Factor VIIa (rFVIIa) (Part 2) in Healthy Subjects

The study will be performed in 2 parts, Part 1 and Part 2. Part 2 has been clinically completed. The remainder of this document concerns Part 1 only. The purpose of Part 1 of this study is to determine the reversal of the blood thinning effects of…

Multicenter Randomized CLinical trial of endovascular treatment for acute ischemic stroke in the Netherlands. The effect of periprocedural MEDication: heparin, antiplatelet agents, both or neither.

To assess the effect of acetylsalicylic acid (ASA) and unfractionated heparin, alone, or in combination, in patients with AIS, who undergo IAT for a confirmed intracranial anterior circulation occlusion.

Long-term follow-up MR CLEAN-NO IV: evaluation of long-term outcomes after acute ischemic stroke.

The aim of this study is to assess the long-term outcomes (up to 36 months) and costs of stroke after EVT treatment, including direct EVT and IVT followed by EVT.

A multicenter, randomized, open-label, blinded endpoint evaluation, phase 3 study comparing the effect of abelacimab relative to dalteparin on venous thromboembolism (VTE) recurrence and bleeding in patients with gastrointestinal (GI)/genitourinary (GU) cancer associated VTE

This study has been transitioned to CTIS with ID 2024-513992-42-00 check the CTIS register for the current data. The primary objective of this study is to assess whether abelacimab is non-inferior to dalteparin for preventing VTE recurrence through…

Prospective randomized multi-center controlled clinical investigation comparing PFO outcomes of the Occlutech Flex II PFO Occluder to standard of care PFO occlusion.

The purpose of this clinical study is the assessment of the safety and effectiveness of the Flex II PFO Occluder in the treatment of subjects 18 years of age or older who have had a cryptogenic stroke due to a presumed paradoxical embolism as…

A Prospective, Multicenter Study of the Indigo* Aspiration System Seeking to Evaluate the Long-Term Safety and Outcomes of Treating Pulmonary Embolism

The objective of this study is to evaluate real world long-term functional outcomes, safety and performance of the Indigo Aspiration System for the treatment of pulmonary embolism (PE)

Balloon pulmonary angioplasty in chronic thromboembolic pulmonary disease without or with mild pulmonary hypertension: BALLOON-TRIAL

to assess the effects of BPA on quality of life and exercise capacity in a group of symptomatic CTEPD patients without PH with incomplete recovery after three month of rehabilitation.

Cancer-associated venous thromboembolism: unfolding the role of the intrinsic coagulation pathway

The primary aim of this study is to compare intrinsic pathway activation between cancer patients with acute VTE and those without VTE. Intrinsic pathway activation will be assessed by measuring coagulation factor complexes with their natural…

The pathophysiology of Deep Vein Thrombosis and Post Thrombotic lesions

To investigate inflammatory processes in (sub) acute DVT at a cellular level.

A multi-centre, randomised, double-blind, placebo-controlled, Phase 2 study to investigate efficacy, safety and tolerability of SLN360 in participants with elevated lipoprotein(a) at high risk of atherosclerotic cardiovascular disease events.

The primary objective is to evaluate the effect of SLN360 on circulating levels of Lp(a) in participants with elevated Lp(a) at high risk of ASCVD events.The secondary objectives are to:• Evaluate safety and tolerability of SLN360 in participants…

Immune checkpoint inhibition associated cardiovascular adverse events in cancer patients

Primary objective: To assess the effect of ICI on progression of coronary non-calcified plaque volume and ICI-related cardiovascular events by measuring differences in plaque burden using repeated CCTA.Secondary objectives:- To evaluate the relation…

FLowTriever All-Comer Registry for Patient Safety and Hemodynamics (FLASH)

The primary study objective is to evaluate the safety and effectiveness of the FlowTriever System for use in the removal of emboli from the pulmonary arteries in the treatment of acute pulmonary embolism (PE). The use of the device will be assessed…

COVID-19 and ischemic stroke - how to tame a dozing monster

(1) Determine the prevalence of (asymptomatic) silent brain infarcts among patients with COVID-19 admitted to after discharge (at least <3 months after positive PCR test) from the hospital, compared with healthy controls.(2) Investigate risk…

A pilot study assessing the feasibility of a randomized controlled trial evaluating aspirin in postpartum women at risk of developing venous thromboembolism

The purpose of this pilot trial is to determine whether it is feasible to conduct a full multicentre randomized controlled trial (RCT) to determine whether low-dose aspirin (ASA) is efficacious and safe at preventing postpartum venous…

A multicenter, randomized, open-label, blinded endpoint evaluation, phase 3 study comparing the effect of abelacimab relative to apixaban on venous thromboembolism (VTE) recurrence and
bleeding in patients with cancer associated VTE (ASTER)

This study has been transitioned to CTIS with ID 2023-509569-19-00 check the CTIS register for the current data. The primary objective of this study is to assess whether abelacimab is non-inferior to apixaban for preventing VTE recurrence at 6…

SARS-CoV2 vaccination and activation of the coagulation system

To explore the change in circulating biomarkers of activation of the coagulation system before and after SARS-CoV2 vaccination (AstraZeneca).

Carotid Artery ImPlant for Trapping UpstReam Emboli
(CAPTURE) for Preventing Stroke in Atrial Fibrillation
Patients

To assess the safety, feasibility, and tolerability of the Vine* Embolic Protection System and implantation procedure in atrial fibrillation (AF) patients at high stroke risk who are unsuitable for oral anti-coagulants (OAC).

Apixaban versus antiplatelet drugs or no antithrombotic drugs after anticoagulation-associated intracerebral haemorrhage in patients with atrial fibrillation. A randomised phase II clinical trial.

Primary Objective: to obtain reliable estimates of the rates of vascular death and non-fatal stroke in patients with atrial fibrillation and a recent anticoagulation-associated ICH who are treated with apixaban versus those who are treated with APDs…

Magnetic Resonance Direct Thrombus Imaging for Suspected Thrombosis of Upper Extremity Diagnostic Evaluation (Selene Study)

Before embarking on a study using MRDTI as sole test to manage clinically suspected UE-DVT, we need to perform a study to determine whether the test has the potential to be useful in patients with suspected UE-DVT. This study has the objective to…

A cohort study evaluating upper extremity function after slender transradial percutaneous coronary intervention

The main objective of this study is to compare upper extremity dysfunction following slender TRPCI using small bore catheters (*5F) compared to standard PCI using regular size guiding catheters(*6F) and conventional stent techniques. Secondary…