Search for a trial

Single center, open-label, non-randomized, non-placebo-controlled study to investigate the pharmacokinetics, metabolic disposition and mass balance after single administration of 25 mg [14C]BAY 2433334 (oral solution) in healthy male participants.

The objective of this study is to determine the mass balance and routes of excretion of total radioactivity after a single oral 25 mg dose of [14C]BAY 2433334 given as solution. For further clinical development, human mass balance data are required…

Evaluation of heart function after physical activity during adjuvant chemotherapy in breast cancer patients: a follow-up study of two previous randomized controlled trials.

To investigate if participation in a moderate to high-intensity exercise program during adjuvant chemotherapy has reduced cardiovascular toxicity in women with breast cancer after an average follow-up of 6 years.

selective prevention of cardiovascular disease witH panElmAnagement and integrated LifeSTYlE inTervention in primARy care (HEALThY HEARt)

The primary goals of this project are to 1) evaluate the effectiveness, 2) identify effective elements and 3) find successful implementation factors of an integrated group-based lifestyle intervention programme in primary care.

Vascular reactivity as a surrogate marker in CADASIL

Primary Objectives: - To determine which technique is most optimal for measuring vascular reactivity in CADASIL patientsSecondary Objectives: - To study CADASIL disease progression over a 17- year time frame - To determine the correlation between…

A Qualitative Phase 1 Study to Development a New Patient-Reported Outcome Instrument for Acute and Chonic Wounds: The WOUND-Q

The aim of our study is to develop a new PRO instrument for acute and chronic wounds. Our 3-phased approach involves a qualitative study, an international field-test and a psychometric study. Patients, healthcare providers and other stakeholders…

Diagnosing cerebral vasculitis using MR intracranial vessel wall imaging at 7.0 tesla

The main research question is to compare the diagnostic accuracy of 7T MRI for cerebral vasculitis, with the standard diagnostic practice (SDP). The true nature of the disease will be assessed for all patients at the end of the study by re-…

Moderate Alcohol and Cardiovascular Health Trial

The primary objective of the MACH15 Trial is to determine the effects of one US serving of alcohol (~15 g) daily compared to no alcohol intake on the risk of incident cardiovascular disease among adults at above-average cardiovascular risk over an…

Treatment of congenital vascular malformations using Sirolimus: improving quality of Life

As patients with congenital vascular malformations often suffer from severe pain and morbidity due to the vascular malformation, quality of life is often signifcantly impaired. The primairy objective of the present study is to reduce pain complaints…

An open-label study to assess the absorption, distribution, metabolism and excretion, including the mass balance of [14C] labeled BIA 5-1058 and metabolites following a single oral dose administration in healthy male subjects

The purpose of the study is to investigate how quickly and to what extent BIA 5 1058 is absorbed, distributed, metabolized (broken down) and eliminated from the body (this is called pharmacokinetics). The investigational compound will be labeled…

IgG4:IgG mRNA ratio as disease activity marker in vasculitis

Aim 1: Confirm the hypothesis that the IgG4 qPCR test score correlates with disease activity in vasculitis as observed in the pilot study. Aim 2: Study IgG4-expressing B-cells from blood of vasculitis patients to understand their role in the…

Long-term follow-up of the offspring born to mothers with a solid organ transplant.

The primary aim of the study is to assess the overall health of offspring born to a mother with solid organ transplantation, and to identify possible pre- and perinatal risks for diseases later in life. In addition, we would like to collect and…