Search for a trial

Relationship between coagulation disturbances and microcirculation alterations and the development of multi-organ failure in sepsis

Investigate the incidence and severity of early coagulopathy in severe sepsis and septic shock patients and investigate the correlation between these coagulation disturbances and the incidence and severity of microvascular changes.

The effects of oral dipyridamole treatment on the innate immune response during human endotoxemia.

Primary objective: The primary objective of the study is to determine the effect of oral dipyridamole treatment on the innate immune response induced by a lipopolysaccharide (LPS) challenge. Various pro- and anti-inflammatory cytokines will be…

The effects of bilirubin infusion on the innate immune response during human endotoxemia.;A parallel open label placebo controlled pilot study.

Primary objective: To determine the effect of hyperbilirubinemia on systemic activation of the innate immune response induced by a lipopolysaccharide (LPS) challenge. Secondary Objective(s): - To determine if hyperbilirubinemia shifts the pro-anti…

The Effects of Transfusion of Red blood cells In Sepsis

To evaluate the effect of age of transfused erythrocytes on expression of *eat me* signals on erythrocytes in several critically ill patient populations (septic and non-septic patients) and to correlate these signals with parameters of impaired…

The effects of iron loading and iron chelation during human endotoxemia.

The primary objective of the study is to determine concentration of circulation cytokines na administration of LPS in the presence of iron sucrose (Venofer®), Deferasirox (Exjade®) of placebo.

The effects of atazanavir-induced hyperbilirubinemia during human endotoxemia.

The primary objective of the study is to determine the effect of atazanavir-induced hyperbilirubinemia on systemic activation of the innate immune response induced by human endotoxemia.Secondary objectives are:- To determine if the vascular…

PREVENTION OF VASOPLEGIA WITH THE USE OF CYTOSORB

To test the efficacy and cost-effectiveness of using CytoSorb in preventing vasoplegia in patients with heart failure undergoing cardiac surgery on CPB.

Detection of hypovolemia in the elderly patient undergoing surgery

The primary aim of the study is to determine the incidence of perioperative hypovolemia in the elderly patient scheduled for major surgery, and how this relates to postoperative complications.

DPP3 levels in out of hospital cardiac arrest patients admitted to the intensive care unit: an explorative study

In this explorative-study, we aim to investigate the relation between cDPP3 release kinetics and clinical outcome parameters in OHCA patients after ICU admission. This could lead to the identification of a new predictive marker, a potential…

Asymptomatic Carotid Surgery Trial -2 (ACST-2). A randomised trial to compare CEA versus CAS to prevent stroke.

The principal and primary research questions are:Primary objective: 1) What are the differences in clinical myocardial infarction (heart attack) rates and in stroke and death within 30 days of carotid stenting compared with carotid endarterectomy?…