22 results
Primary objective: To show that the variability of whole blood total and unbound plasma tacrolimus concentrations during the first 6 days post transplantation is larger than the variation of tacrolimus concentrations in stable clinical situation.…
The objective of the current study is to assess the effect of speed optimization on clinical and echocardiographic parameters at 3 months follow-up.
The objective of this study is to collect clinical data on safety and performance of ACUITY X4 leads when used outside a clinical trial in a standard clinical setting.
In this study we will assess the effects of exenatide on cardiac metabolism and function in patients with T2DM and CHF. We will address the following hypothesis: exenatide improves global cardiac function in CHF patients with T2DM, by favorable…
To assess changes in left ventricular performance using echocardiography as well as ventricular remodelling, changes in sleep and changes in mood, anxiety and cognitive functions occurring as a result of treatment of predominant central sleep apnoea…
We would like to evaluate the beneficial effects of fibrate treatment on muscle mitochondrial and cardiac function in patients with NLSDM.
The primary objective is to continue to assess the long term safety of the CardioKinetix Parachute Implant System in the partitioning of the leftventricle in patients with heart failure due to ischemic heart disease.
The primary hypothesis of our study is that volumetric monitoring will allow for more effective and targeted fluid administration compared to pressure (PAC) monitoring, thereby allowing the attending physician to better optimize fluid infusion…
Objective: -To investigate the effects of recombinant human erythropoietin (rHu-EPO) on myocardial perfusion and efficiency in patients with CHF using positron emission tomography (PET) and cardiac magnetic resonance (CMR).Secondary objectives: -To…
The proposed study aims to assess the technical reliability and user friendliness of the Intel platform in 25 patients who are in stable heart failure. Subsequently, the cost-efficacy of the technology will be assessed in 100 patients with a focus…
to study the effect of short term combined use of NSAIDS with diuretics/RAAS-inhibitors on the heart and kidneyfunction in orthopedic patients undergowing a knee- or hip-replacement
1. IS there an effect of short-time combined use of NSAIDs and diuretics/RAAS-inhibitors on the heart- and kidneyfunction in orthopaedic patiënts who undergo a total knee- or hipreplacement.2. Is cystatin C a better endogenous marker of kidney…
The purpose of this trial is to evaluate the long-term effects and cost-effectiveness of adaptive servo-ventilation (ASV) on the mortality and morbidity of patients with stable heart failure due to left ventricular systolic dysfunction, already…
The primary objective of this study is to demonstrate that individually optimized, triple-site biventricular pacing is superior to standard biventricular pacing in reversing ventricular modeling as demonstrated by Echo Left Ventricle End-Systolic…
The general objective is to study gender differences in the magnitude of CRT response in a HF population with an equal distribution of women and man in order to examine the interrelationship among CRT effect, gender and baseline clinical factors (e.…
The main purpose of this study is to assess the impact of arterial stiffness on the response in 24h ambulatory blood pressure reduction following renal sympathetic denervation in patients with primary hypertension with or without diastolic…
The primary objective of this study is to assess the safety and tolerability of sacubitril/valsartan compared with standard of care used for treating BP in patients that have been implanted with the HM3 LVAD.
This study has been transitioned to CTIS with ID 2024-518803-23-00 check the CTIS register for the current data. To evaluate the safety and efficacy of DOAC versus VKA in CTEPH/CTED patients receiving BPA, based on the composite endpoint of…
This study aims to assess the safety and efficacy of the remed*® system in adult patients with moderate to severe central sleep apnea in real life.
The objectives of the study are to describe:1. The efficacy of the Edwards Cardioband Mitral System in improving mitral regurgitation, functional status, and quality of life.2. The safety of the Edwards Cardioband Mitral System.