412 results
Primary objective:The primary objective is aimed at determining the comparability of intracardiac impedance (ICI) measurements to echocardiographic reference parameters in assessment of changes in stroke volume (SV) in an acute setting. It is…
The primary goal of the study is to assess whether a goal oriented strategy to preserve/improve right ventricular function by application of upfront combination therapy will improve clinical outcome. Study questions:1. Will a goal oriented strategy…
In the present clinical investigation, we will perform an analysis of baseline risk factors to identify predictors for appropriate ICD intervention in patients with ischemic cardiomyopathy receiving an ICD for primary prevention (MADIT II population…
- To assess whether a disease specific educational website improves self-care behaviour and quality of life of patients with HF as compared to usual care.- To assess whether a disease-specific educational website plus an interactive web-based…
The efficacy of PRDN will be evaluated primarily using echocardiographic parameters. Also, safety of PRDN on major and minor adverse events, LV mass, LV and LA dimensions, MIBG uptake and clinical endpoints will be evaluated. The results of the…
The primary aim of this observational study is to determine the occurrence of (exercise-induced) pulmonary hypertension (sPAP > 40 mmHg) in IIP patients with an elevated V*E/V*CO2 at AT (> 34) assessed during CPET. And, secondly to…
The Cardiomyopathy Registry Study (CARS)-II aims to1) Create a national cohort with biorepository of patients with paediatric DCM2) To elucidate (epi) genetic causes of iDCM in a uniform and state of the art way.3) Identify clinical risk factors for…
To determine the efficacy and safety of the CardioFit system for the treatment of subjects with systolic heart failure who have failed to achieve symptom relief through standard evidence-based management per applicable guidelines.
Primary objective: To compare the impact of a single day of prolonged walking exercise on cardiac function and biomarker responses between heart failure patients and their age- and sex-matched controls.Secondary objective: To compare the impact of 1…
The primary objective of the PASSENGER study is to investigate any relationship between changes in SonR1 augmentation and a change in patients* exercise capacity as assessed by the 6 Minute Walk Test.
The main objective is assessment of safety and feasibility of intravenous administration of autologous, in vitro expanded, mesenchymal stem cells in patients with pulmonary arterial hypertension due to systemic sclerosis. The secondary objective is…
To study remodeling patterns of the left and right ventricle in patients with pulmonary arterial hypertension who underwent lung transplantation, using cardiac magnetic resonance imaging.
The objective of the current study is to assess the effect of speed optimization on clinical and echocardiographic parameters at 3 months follow-up.
This study evaluates the normal range dynamic contrast-enhanced MRI bolus kinetic parameters in healthy subjects. The sensitivity of the bolus kinetic parameters to fluid challenges is evaluated. The correlation between change in thoracic impedance…
The objective of this study is to collect clinical data on safety and performance of ACUITY X4 leads when used outside a clinical trial in a standard clinical setting.
The primary objective of this trial is to investigate the bias, limits of agreement and percentage error of cardiac output measurements with Vigileo FloTrac, transoesophageal doppler ultrasound, thoracic bioreactance (NICOM) with the CO obtained…
Primary Objective: To study known heartfailure biomarkers (proteomics, microRNAs and metabolomics) for the detection and prognosis of cardiotoxicity in patients receiving antineoplastic therapy, and to discover predictive biomarker (values). In the…
Employing PPCM patient-derived iPSCs, we aim to test our hypothesis that cardiomyocytes from PPCM patients exhibit (epi)genetically determined differences in protein expression profiles and functional behavior in comparison to those from healthy…
The purpose of the study is to investigate how quickly and to what extent BAY 1021189 is absorbed, distributed, metabolized (broken down) and eliminated from the body (this is called pharmacokinetics). The compound to be administered will be labeled…
Primary objective: To assess the safety and efficacy of endovascular renal nerve ablation using the Boston Scientific Vessix V2 renal denervation system in patients with systolic heart failure