412 results
1) elucidate the role of the postural CO decrease on cerebral hemodynamics, 2) test the influence of posture, ageing and T2DM on the CO-VO2 relationship. Furthermore, 3) we want to determine the shape of the CO-VO2 relationship.
The primary objective of the present study is to demonstrate that maintaining sinus rhythm after ECV for persistent AF in patients with severe chronic heart failure and reduced ejection fraction reduces NT-proBNP levels.
The objective of this study is to investigate whether D-VCG can be used to determine the optimal AV- and VV-interval and whether VCG and LVLED can be used to determine the optimal LV lead position. Primary objectives: 1) To investigate whether D-VCG…
The main objective of this study is:• To determine the optimal site to position the left ventricular pacing lead for each individual patient with an ischemicCardiomyopathy (CMP). The site is selected based on the latest mechanical activated site and…
The main aim of the present study is to validate a predictive multiparametric algorithm to predict the response to CRT in terms of the amount of decrease in LV end systolic volume (LVESV). The model combines typical left bundle branch block (LBBB)…
The primary objective is to gain insight into the causative mechanisms of exertional dyspnea in HFPEF. We hypothesize that exercise induced pulmonary hypertension plays a significant role in the development of complaints. The secondary objectives…
The primary objective is to assess the safety of the CardioKinetix Parachute Implant and Delivery System in the partitioning of the left ventricle inpatients with heart failure due to ischemic heart disease.
To investigate the clinical efficacy in detecting clinically relevant arritmia's (especially AF) of the Reveal XT in patients with mild to moderate heart failure and elevated risk factor for stroke and TIA (CHADS score), currelently not treated…
Compare usual care in patients with treatment resistant heart failure with additional ultrafiltration by peritoneal dialysis.
The aim of the present study is to examine the effect of integrated telemonitoring and telecare, compared to usual care, on quality of life and hospitalization in patients with heart failure in primary care.PrimaryTo examine the effect of integrated…
The main objective of this observational study is to examine DPA in HF patients (NYHA II and III) by means of accelerometry. The secondary objective is to assess the influence of a number of psychosocial determinants (e.g. self-efficacy, intrinsic…
Primary objective:The main aim of the current study is to identify novel pathophysiological pathways associated with the development of post-MI HF using genome-wide data and innovative bioinformatics approaches. Specific aims1) Identifying and…
Quantify how many frail elderly aged over 65 years with reduced exercise tolerance and/or exercise induced dyspnoea have previously unrecognised COPD and heart failure.Quantify the difference in prevalence of unrecognised COPD and heart failure…
The overall aim of this project is to compare acute and chronic effects of moderate versus high intensity exercise training in HF patients. Specifically, we will:1. Compare the effects of *traditional* moderate intensity versus novel high intensity…
The current proposal wants to examine the efficacy and cost-efficiency of a telemonitoring solution to improve medication adherence in chronic heart failure patients, to enhance the clinical state of the patients and to reduce health care…
The primary objective of this randomized, open label single centre trial is to compare dopamine versus no dopamine on top of standard treatment in patients with exacerbation of severe heart failure (NYHA class III-IV) in home situation. This study…
The aim of our study is to identify the same 4 circulating analytes identified in the animal models in human subjects. An additional task will be to measure the basal levels and the inter-individual variability.
The primary objective is to determine if echocardiography in combination with plasma biomarkers can be used as a potential predictor for pulmonary hypertension. The secondary objectives are assessment of a potential correlation between…
1. To assess prevalence of SAS in a Dutch chronic heart failure (CHF) population. 2. To assess whether there are group differences between CHF-patients without SAS and CHF-patients with SAS (OSAS and CSAS). 3. To assess the validity of the ApneaLink…
The primary objective of the study is to determine whether the optimal atrioventricular delay and interventricular delay in cardiac resynchronization therapy are a function of exercise. Secondary objectives are the development of an automatic…