345 results
Primary Objective: To compare the effects of hypothyroidism and hyperthyroidism on cardiac left ventricular function, as assessed by CMR, in subjects with differentiated thyroid cancer during their early treatment.Secondary Objective(s): To compare…
Primary Objective • To assess the effects of 80mg of furosemide delivered by subcutaneous delivery in the abdominal area over 5 hours when compared to oral administration in patients with heart failure with chronic fluid overload. Secondary…
To investigate whether circadian rhythms in patients with chronic systolic heart failure are disturbed
The overall purpose of the study is to determine the effectiveness of structured introduction and access to a Wii game computer in patients with heart failure (HF) to improve their exercise capacity, their daily physical activity, decrease health…
1) To study the late effects of 131-I treatment and TSH suppressive therapy as well as quality of life in patients with childhood-onset DTC. 2) To determine the presence of RET/PTC 1 and 3 translocations and BRAF mutations, and to investigate their…
The aim of this study is to evaluate the effects of treatment on the exertional contractile reserve and RV-arterial coupling during exercise in CTEPH patients. Furthermore, we evaluate the effects on the exertional contractile reserve and RV-…
The objective of this study is to assess the safety and effectiveness of the automatic atrioventricular (AV) delay and interventricular (VV) delay optimization algorithm used in the PARADYM RF SONR Cardiac Resynchronization Therapy with…
Primary Objectives: - To investigate whether disease progression in individual patients with CHF can be accurately assessed by serial measurements of disease-related (novel) biomarkers.- To investigate whether dynamic biomarker patterns as…
Demonstrate the superiority of finerenone to eplerenone in delaying time to first occurrence of the compositeendpoint, defined as cardiovascular (CV) death or hospitalization for heart failure (HF), in patients withCHF (NYHA class II-IV) and reduced…
Primary Objective: -To test the feasibility of MRI and CT fusion with 3D rotational venogram / fluoroscopy for left ventricular lead positioning in CRT.Secondary Objectives: -Visualize the location and distance to LV lead position of MRI determined…
The primary objective of the present study is to demonstrate that NT-proBNP guidance during in-hospital treatment for acutely decompensated heart failure (to strive for >30% reduction) reduces readmissions and mortality and increases the…
Is to identify the incidence and prevalende of PH in premature born infants. In addition we will identify possible risk factors for the development of PH and we want to determine the prognosis and survival of these patients. PrimaryTo determine the…
Primary Objective: Evaluation of the benefit of IABP counterpulsation in patients with diuretic-resistant congestive heart failure. Secondary Objective(s): - To lower the burden of disease/improve symptoms, to shorten duration of stay in the…
Objective with respect to patient care: Obese patients have an increased risk of developing heart failure. By gaining insight on the role of obesity in cardiac dysfunction it will be possible to provide a better risk stratification for the onset of…
Hypothesis - Our hypothesis is that TNF blocking medication improves cardiac function in patients with active RA. Objectives - Primary objective: to investigate the effect of TNF blocking therapy on diastolic left ventricular (LV) function in RA…
To determine the tacrolimus bioavailability after tacrolimus administration via a rectiole.
The purpose of the study is to investigate how quickly and to what extent neladenoson bialanate is absorbed, distributed, metabolized (broken down) and eliminated from the body (this is called pharmacokinetics). Neladenoson bialanate to be…
To study patients with severe HF who would benefit from off-pump SVR using the Revivent Myocardial Anchoring System. To investigate the characteristics of the ischaemic heart using CMR or cardiac CT in order to verify patient eligibility for the…
The primary objective of the study is to determine whether the intrinsic electrical delay (QLVs) at a specific pacing site is correlated to acute hemodynamic response (by percentage increase in strokework, %SW) in CRT with a quadripolar lead.
Primary Objective:To demonstrate that serelaxin is superior to placebo in reducing CV death in AHF patients during a follow-up period of 180 days.To demonstrate that serelaxin is superior to placebo in reducing worsening heart failure through Day…