115 results
Primary Objective: To compare the effects of hypothyroidism and hyperthyroidism on cardiac left ventricular function, as assessed by CMR, in subjects with differentiated thyroid cancer during their early treatment.Secondary Objective(s): To compare…
To investigate whether circadian rhythms in patients with chronic systolic heart failure are disturbed
Main objective: To investigate whether spironolactone can favourably alter extra-cellular matrix remodelling, assessed by changes in the fibrosis biomarker Procollagen Type III N-Terminal Peptide (PIIINP), in patients at increased risk of developing…
The primary objective is to demonstrate that rivaroxaban is superior to placebo in subjects with chronic HF and significant CAD, who are receiving standard care, in reducing the risk of the composite of ACM, MI, or stroke following a recent…
The aim of this study is to evaluate the effects of treatment on the exertional contractile reserve and RV-arterial coupling during exercise in CTEPH patients. Furthermore, we evaluate the effects on the exertional contractile reserve and RV-…
Primary Objectives: - To investigate whether disease progression in individual patients with CHF can be accurately assessed by serial measurements of disease-related (novel) biomarkers.- To investigate whether dynamic biomarker patterns as…
Is to identify the incidence and prevalende of PH in premature born infants. In addition we will identify possible risk factors for the development of PH and we want to determine the prognosis and survival of these patients. PrimaryTo determine the…
Objective with respect to patient care: Obese patients have an increased risk of developing heart failure. By gaining insight on the role of obesity in cardiac dysfunction it will be possible to provide a better risk stratification for the onset of…
The primary objective is to establish the point prevalence of Airflow Limitation (AL) compatible with COPD in patients with congestive heart failure (CHF) seen in a single centre in the Netherlands.
2. STUDY OBJECTIVESSpecific Aim 1. To determine whether Tako-Tsubo cardiomyopathy is associated with hyper reactivity of the neurohormonal and cardiovascular systems. Hypothesis 1: Patients with a clinical history of Tako-Tsubo cardiomyopathy have…
Primary objective: To compare the impact of a single day of prolonged walking exercise on cardiac function and biomarker responses between heart failure patients and their age- and sex-matched controls.Secondary objective: To compare the impact of 1…
Employing PPCM patient-derived iPSCs, we aim to test our hypothesis that cardiomyocytes from PPCM patients exhibit (epi)genetically determined differences in protein expression profiles and functional behavior in comparison to those from healthy…
The primary objective is to gain insight into the causative mechanisms of exertional dyspnea in HFPEF. We hypothesize that exercise induced pulmonary hypertension plays a significant role in the development of complaints. The secondary objectives…
The main objective of this observational study is to examine DPA in HF patients (NYHA II and III) by means of accelerometry. The secondary objective is to assess the influence of a number of psychosocial determinants (e.g. self-efficacy, intrinsic…
Primary objective:The main aim of the current study is to identify novel pathophysiological pathways associated with the development of post-MI HF using genome-wide data and innovative bioinformatics approaches. Specific aims1) Identifying and…
The main objective is to illuminate the effect of S 44121 (restores the Ca²+ release channel function by improving the rebinding of the channel-stabilizing subunit (calstabin)) versus placebo administered orally for a total of 12 weeks on MTWA in…
Aim of the Maastricht StudyThe primary objectives of the Maastricht Study are:1. to study the development of obesity, the metabolic syndrome and type 2diabetes in the general population.2. to study the development of cardiovascular disease in the…
The objective of the study is to investigate effects of training on insulin resistance (IR), chronic heart failure (CHF) and cognition of resthome residents.
The primary objective of this study is to asses whether HIF signaling pathways show less activity in patients with preserved ejection fraction compared to patients with systolic dysfunction. Secondary objectives are to assess the relation between…
The major research objective is to investigate 1) whether lowering cardiac and muscular lipid content will improve mitochondrial and cellular function in type 2 diabetic patients, and 2) whether this lipid lowering effect also improves uncoupling in…