86 results
The main objective of this pilot study is to determine the effects of vascular access construction on autonomic and cardiac function.
Primary objective:1. To identify new and/or additional markers for predicting absolute (and/or functional) ID in chronic HF and compare these serum markers to the gold standard of BM iron staining. Secondary objectives:2. To investigate the…
To examine the long-term effects of a CT- and/or RT-induced premature menopause on BMD, cardiovascular status, neurocognitive function and QoL in female HL survivors.
In the current study we will re-examine the participants of the CODAM study in a second follow-up evaluation (12 yrs after baseline) in order to obtain further longitudinal information on the natural development of type 2 diabetes and cardiovascular…
This study will address the mechanisms of DHF by identifying the role of biomarkers in the process of neurohormonal activation, cytokine activation and oxidative stress, the role of biomarkers at myocardial level in the process of cardiomyocyte cell…
The aim of this study is to identify direct markers of muscle and adipose tissue hypoxia in COPD and CHF patients in relation to the altered muscle oxidative phenotype and the putative mediators HIF-1α and PPARs/PGC-1. Insight in the underlying…
Aim is to establish the relation between plasma and tissue AGE levels and the severity of diastolic/vascular dysfunction and its relation with symptoms in patients with type 2 DM with and without CHF, and in patients with CHF without DM. Primary…
We aim to investigate which part of the pulmonary vasculature, the obstructed or non-obstructed, is responsible for the pulmonary vasodilator response.
To investigate the genetic, genomic and proteomic basis of hypertension and susceptibility to hypertension-related target-organ damage (renal insufficiency and heart failure).
The primary objective of the study is to explore the efficacy of intensive bicycle exercise test to induce cardiac micro-injuries by measurement of serum concentrations of hs-troponin I in healthy volunteers. The secondary objectives of this study…
To investigate whether the expression of renal water and sodium transporters in urinary exosomes is different in compensated versus decompensated liver and heart disease.
The major research objective is:- to examine whether elevation of plasma FFAs results in cardiac lipid accumulation and whether this influences cardiac function negatively.Additional research objective: - to examine whether cardiac lipid content is…
If certain combinations of micro RNA's that are predictive for recovery exist, they can be improtant for prognostic reasons and play a role in postponing device implantation. It may also help in choosing the right pharmaceutic regiment.
To compare sympathetic and haemostatic activity in rest and after rising in patients with chronic heart failure and healthy subjects, who will be randomly assigned to selective and nonselective beta-blockers. To analyse whether haplotypes of two…
Aim is to establish the relation between skin AGEs, measured as skin-autofluorescence, and diastolic dysfunction. Primary Research Questions1. Is there a relation between skin-autofluorescence and the severity of diastolic dysfunction in patients…
To study the possible beneficial effect of simvastatin on accumulation of triglycerides in the myocardium of patients with DM2 and the effect on vessel wall thickness using magnetic resonance imaging and spectroscopy
To establish the relation between myocardial, serum and skin AGE levels. To determine the quantitative AGE-levels in myocardial tissue
1. To determine if beta2-receptor polymorphisms influence the probability of recovery of heart failure.2. To determine possible other factors that influence the probability of recovery in our patient cohort.3. To determine the amount of LVEF…
1) To assess whether a correlation exist between the degree of pulmonary clearance of free radical positive white bloodcells and platelets and the degree of pulmonary congestion in congestive heart failure (CHF) patients2) To asses whether cardiac…
We aim to investigate whether this damage results from altered pulmonary blood flow patterns and related increases in shear stress and vascular remodelling. To test our hypothesis we will make use of novel techniques to quantify pulmonary perfusion…