39 results
2.1 Primary objectiveTo determine patterns of response in the transvalvular pressure gradient while altering transvalvular flow.2.2 Secondary objectives-To quantify any added value or differentiation from stress assessment of aortic stenosis…
Primary objective: To validate the quantification of AR by time-densitometry on contrast aortography with the gold standard of CMRI measurements in order to refine the interpretation and evaluate the accuracy of the qRA method. Secondary objective:…
Compare hemodynamic parameters and flow patterns of the stented Mitroflow bioprosthesis, stentless Freedom SOLO bioprosthesis,transcatheter Edwards Sapien bioprosthesis and healthy control subjects, measured with 4D flow MRI.
The primary objective is to investigate cerebral perfusion in rest and in response to moderate exercise (handgripping or light cycling) and a visual stimulus in patients with severe aortic valve stenosis prior and after surgical or transcatheter…
To determine normal FDG-uptake around PHV*s in aortic position.
To study the biological variation of cardiac biomarkers (e.g. cardiac troponin T and I, NT-pro-BNP, ST-2, Galectin-3) in clinically stable moderate aortic valve stenosis.
We aim to i) describe flow patterns and flow-related dynamics in the ascending aorta of patients with aortic valve stenosis, ii) compare these flow parameters before and after surgical aortic valve replacement and iii) compare flow parameters with…
To determine the effects of surgical and transcatheter (transapical, transfemoral or transaortal) aortic valve replacement on patient neuropsychological functioning which provides the opportunity to prematurely establish subclinical effects that may…
Predicting fluid responsiveness during PLR and fluid challenge (FC) by changes in (Pms).
To determine normal values in stress echocardiographic parameters in asymptomatic patients at least 6 months after successful MV repair for organic MV regurgitation. These normal values for non-invasive 2D stress echo testing are of utmost…
The main objective of the single center, observational study is to assess the immediate and long term effects of TAVI on LVF and coronary flow by means of pressure volume loops, intracoronary flow assessment, echocardiography and cardiac MRI/CT.…
This study is aimed at evaluate whether the microTEE can be used in stead of the current TEE probe, or intracardiac ultrasound catheters (ICE) in adults with a structural heart disease. The aim of the study is to compare image quality, the workflow…
Primary objectives:- Evaluation of the value of mBL as a diagnostic tool for bacterial endocarditis.- Evaluation of the value of mBL as a monitoring tool during treatment for bacterial endocarditis.- To obtain data on the kinetics of mBL related to…
The main objective of the single center, observational study is to assess the immediate and long term effects of TAVI on biomarkers, correlated to clinical outcomes.
To evaluate the effects of MitraClip implantation on:* mitral inflow patterns during exercise* the atrial septum, moreover the persistence of the iatrogenic atrial septal defect and the consequential risk of right atrial and ventricular dilatation…
This study is performed to asses the effect of MECC system compared to CECC in patients undergoing aortic valve surgery on microemboli in the form of high intensity transient signals (HITS) detected by Transcranial Doppler Ultrasonography (TCD).…
The objective is to assess the degree of under- and overexpansion and malapposition of the CRS after implantation, and to come with a proposal of sizing based upon observations made in a (large) prospective clinical data set-experience. For this…
Evaluation of the morbidity and mortality rate at 3 and 12 month follow-up in patients implanted with Freedom SOLO prosthesis.
Primary Objective: The association between the functional improvement (change in VO2 max) and DSE parameters will be determined. In this way the diagnostic characteristics of DSE will be investigated.Secondary Objective(s): The influence of the…
The exact mechanism behind the observed fast recellularization of the DTEHV constructs is still unknown. A reasonable explanation might be that scaffold remnants inside the tissue-engineered constructs recruit the circulating blood cells. In order…