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A phase II, randomized, double-blind, placebo controlled, parallel design, dose ranging, multi-center trial of four levels of exposure of QGE031 s.c. for 16 weeks in subjects aged 18-50 years with peanut allergy (CQGE031A2208)

Primary: To characterize the QGE031 dose response relationship for the increase in the threshold dose of peanut protein that induces objective hypersensitivity reactions after treatment.Secondary (only key parameters): The percentage of patients…

Patch-test cross-reactivity to a novel, probably non allergenic hair-dye precursor (PPD-derivative F000175918)

Objective: Determination of cross-reactivity to a newly developed PPD-derivative (F000175918) in previously PPD-sensitized patients. Hypothesis:Since PPD-derivative F000175918 is categorized as a moderate sensitizer, based on pre-clinical…

*Evaluation of the effect of probiotics on development of asthma and allergic rhinitis during childhood - follow-up study at age 5 or 6 years*

Objective: To establish the effect of perinatal probiotics on the prevalence of allergic disease at the age of 5 or 6 years.

Periodontitis and Rheumatoid Arthritis; a link by protein citrullination? A cross-over clinical trial

To assess periodontitis-with P. gingivalis in particular- as a pathogenic factor in disease progression of RA.

Evaluation of the effect of early BCG-vaccination on development of asthma and allergic rhinitis during childhood - follow-up study at age 7 years.

To establish the effect of BCG vaccination in 6 weeks old high-risk infants on the prevalence of asthma and allergic rhinitis at the age of 7 years.

Translational research to study the role of regulatory cells in allergy early in life and the induction of regulatory cells in cord blood

Objective: How do T cells in cord blood respond to heat shock proteins, allergens and anti-CD3 Are stimulus specific Tregs induced during these responses and can these responses be suppressed by naturally occurring cord blood Tregs in vitro.

Further development and validation of the daily hay fever forecast by symptom monitoring using modern information- and communication technology

1. To investigate whether the currently used hay fever forecast correlates with the symptoms that grass pollen allergic patients report directly using a new communication system that allows direct control, and whether the model can be improved.2.…

Plant stanol esters in the prevention of clinical symptoms related to asthma: the PLANTASTIC trial

The primary objective of this study is to demonstrate clinical benefits of prolonged consumption of plant stanols (delivered via plant stanol esters) in asthma patients. The secondary objectives are to evaluate the mechanisms via which plant stanols…

A randomised, double-blind, controlled, parallel-group, multi-country study to investigate the effect of a partially hydrolysed infant formula with added synbiotics on gut microbiota composition and clinical effectiveness in infants at high risk of developing allergy.

The aim of the present study is therefore to investigate the bifidogenic effect of a hypoallergenic formula (based on partially hydrolysed whey protein) supplemented with a specific combination of prebiotics and probiotics (synbiotics) compared to…

A randomised, double-blind, controlled, parallel-group, multi-country study to investigate the effect of a partially hydrolysed infant formula with added synbiotics on the development of allergic manifestations in infants at high risk of developing allergy.

This study investigates the preventive action of formula with partially hydrolysed cow milk protein supplemented with pre- and probiotics in the development of allergy. The goal of the study is to investigate the efficacy, the growth and the safety…