14 results
Primary objectivesLongitudinal quantification of the total latent HIV reservoir with determination of the size of the replication competent HIV reservoir and investigate potential biomarkers of the HIV reservoir size and nature.Cross compare the…
To generate a set of normal values in people over 60 that can be expected to have an normal immune system, in order to be able to interpret the immune system of eldery patients with repeated airway infections.
To investigate if ultra low-dose chest CT may be a better diagnostic tool than chest X-ray on day 1 of febrile neutropenia. Imaging results will be compared with a consensus diagnosis on the cause of febrile neutropenia made by an expert panel.…
The aim of this study is to investigate immune response to pneumococcal vaccination in patients after community acquired pneumonia with S. pneumoniae compared to pneumonia patients with another pathogen.
This study aims to investigate the effect of switching from Atripla® to Eviplera® on neurocognitive performances (neurocognitive testing) and imaging (functional MRI scanning) in virologically suppressed HIV-infected patients and stable on atripla.
Our primary objectives are:- to estimate the prevalence of central adrenal insufficiency , defined as a plasma cortisol response <500 nmol/l in the low-dose ACTH test (see paragraph 8.3.5 of the protocol). - to describe immune dysfunction, i.…
Hypothesis:- The height of the result of the MTB-specific assays is directly related to the number of MTB bacilli present. As a result, effective treatment of persons with LTBI will cause a decrease of the quantitative test result and finally a…
Primary Objective: Create a complete transcriptome of blood cells from dichotomous HIV-2 infection.Secondary Objective(s): Define host factors and pathways that are implicated in the pathogenesis of HIV infection. Determine of the mechanisms that…
Investigation of the blood B cell compartment in family members of CVID patients (with and without a CVID family history) to identify or exclude B-cell defects and to improve our insight into a potential familial background of CVID.
Primary Objective: • To develop new criteria for the interpretation of the IgG response to pneumococcal polysaccharide vaccination using serotype-specific normal values.Secondary Objectives: • To develop criteria for the interpretation of the IgG1,…
Main objective: to validate a screening algorithm for PAD in a primary care setting in the Netherlands. Secondary objective: to improve the screening algorithm based on obtained results
Objective: The primary objective of this study is to investigate the potential of the custom global screening array (GSA) in patients with autoinflammatory disorders. We aim to investigate whether the GSA can pick up genetic variants in genes known…
This study aims to investigate the effect of switching from Atripla® to Eviplera® on neurocognitive performances (neurocognitive testing) and imaging (functional MRI scanning) in virologically suppressed HIV-infected patients and stable on atripla.
Primary Objective: To assess dietary intake of macro- and micronutrients, body composition and serum levels of nutrients in patients with primary antibody deficiency and bronchiectasis. Secondary Objective(s): - To evaluate the correlation between…