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SARS-CoV-2 specific immunity in patients with congenital immune deficiencies

With this study, we want to gain insight in the SARS-CoV-2 specific immunity (T- and B-cell) of patients with congenital immune disorders. This will add to our knowledge on SARS-CoV-2 specific immunity, and on the immune capacity of the patients…

Convalescent Antibody-Mediated Treatment of COVID-19 Infections in Patients with B-cell dysfunction, a Randomized Trial (COVID-Compromise Study).

There have been reports of a more serious course of COVID-19 infections in patients with a reduced immune system, such as patients with congenital immune disorders, (haematological) malignancies or patients taking medications that suppress the…

Influencing Progression of Airway Disease in Primary Antibody Deficiency

Objective: To show the protective value and to measure cost effectiveness of higher Ig dosing on progression of lung disease in PAD.

SARS-CoV-2 vaccination response in people living with HIV

Main study: primary vaccination regimenPrimary Objective: 1. To determine the difference in the antibody response against SARS-CoV-2 in PLWH 4 weeks after the completed vaccination schedule with one of the two available mRNA vaccines (BNT162b2 or…

A Phase 1, Single-blind, Randomized, Parallel-group Study in Healthy Participants to Investigate the Single-dose Pharmacokinetics, Safety and Tolerability of Rilpivirine After Subcutaneous Administration of a Rilpivirine Extended-Release Suspension alone, and of Rilpivirine and Cabotegravir After Co-administration with Cabotegravir Extended-Release Suspension

To characterize the single-dose pharmacokinetic (PK) of RPV after SC administration of RPV LA suspensions with different doses and/or different particle size (PS) to support further dose and formulation selection, in healthy adult participants.To…

Early detection of primary antibody deficiencies in primary care facilities by an algorithm driven selection of serologic testing in individuals at risk.

Main objective: to validate a screening algorithm for PAD in a primary care setting in the Netherlands. Secondary objective: to improve the screening algorithm based on obtained results

Vaccination Against Covid in Primary Immune Deficiencies

To assess immunogenicity and safety of SARS-CoV-2 vaccination in patients with isolated antibody deficiencies, i.e. patients with immunoglobulin G (IgG) subclass deficiency and patients with selective antibody deficiency with normal immunoglobulins…

Influencing Progression of Airway Disease in Primary Antibody Deficiency

This study has been transitioned to CTIS with ID 2024-513124-41-00 check the CTIS register for the current data. To show the protective value and to measure cost effectiveness of higher Ig dosing on progression of lung disease in PAD.