12 results
The objective of the study is to improve the detection of sepsis in primary care by developing a clinical decision rule for GPs, consisting of the most relevant clinical features and point-of-care (POC) measurements of biomarkers. This decision rule…
To test if a CRT-targeted resuscitation based on clinical hemodynamic phenotyping can improve a hierarchical clinical outcome - mortality, time to cessation of vital organ support, and length of hospital stay, all within 28 days - in septic shock…
The primary objective of this study is to determine the relation of delta PO2 (PaO2-tcPO2) and delta PCO2 (tcPCO2-cPCO2) levels to sepsis. The secondary aims are to determine the factors that influence delta PO2 and delta PCO2 and to determine the…
This study has been transitioned to CTIS with ID 2023-507889-89-00 check the CTIS register for the current data. REMAP-CAP: The goal of the study is to investigate the best treatment regime for pneumonia patients. For non-pandemic pneumonia (…
Our main aim is to develop a biomarker-based method to decide whether treatment with antibiotics is required for treatment of individual hospitalized AECOPD patients. We hypothesize that our biomarker-based intervention, using PCT levels to guide…
This study is designed to confirm the safety and efficacy of PLASOMA after CE marking:1. in a larger population,2. in a more diverse population, consisting also of non-diabetic wound types, and3. including long-term safety.and to determine the…
The aim is to reduce SSI in PWT2D by implementing a proactive basal-bolus insulin regimen, compared to a widely used reactive sliding scale regimen. It is hypothesised that a proactive basal-bolus insulin regimen targeting glucose levels of 3.9-10…
The primary objective of this study is to evaluate the personalized hemodynamic resuscitation protocol, guided by the Baxter Starling, for sepsis patients within the first six hours after admission to the emergency department, in comparison to the…
To compare the safety and efficacy of different doses and regimens of Allocetra-OTS to that of Placebo in the treatment of organ failure in adult sepsis patients
Primary: To determine whether three months of prophylactic treatment with co-trimoxazole causes a reduction in the number of days a child experiences at least two RTI symptoms in children aged 6 months to <=10 years with recurrent RTIs, when…
This study has been transitioned to CTIS with ID 2024-513124-41-00 check the CTIS register for the current data. To show the protective value and to measure cost effectiveness of higher Ig dosing on progression of lung disease in PAD.
The objective of this pilot study is to assess whether transportation of the sample via a pneumatic tube system (PTS) has any detrimental effects on the recovery of presepsin levels, when compared to traditional hand-delivery. This research will be…