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A Multicenter randomized trial, comparing a 25G EUS Fine Needle Aspiration (FNA) device with a 20G EUS ProCore Fine Needle Biopsy (FNB) device

To compare the performance and diagnostic accuracy of two EUS-guided tissue acquisition devices; a 25G Echotip Ultra Fine Needle Aspiration (FNA) device and a new, more flexible, 20G Echotip ProCore Fine Needle Biopsy (FNB) device.

Minimally invasive versus open pancreatoduodenectomy

The objective of the LEOPARD-2 trial is to assess the safety of MIPD versus OPD and after that to assess the time to functional recovery of MIPD versus OPD for symptomatic benign, premalignant or malignant peri-ampullary disease.

A feasibility study comparing two strategies of oral contrast in patients undergoing contrast-enhanced abdominal CT: 50 ml Télébrix Gastro + 950 ml water vs 1000 ml water only.

The aim of this study is to compare the image quality, diagnostic confidence and patient discomfort when using either positive (50 ml Télébrix Gastro + 950 ml water ) or negative 1000 ml water only in outpatients undergoing a contrast-enhanced…

Laparoscopic versus open distal pancreatectomy for symptomatic benign, premalignant and malignant disease

To determine whether time to functional recovery is shorter after LDP than after ODP for symptomatic benign, premalignant and malignant disease of the distal pancreas in an enhanced recovery setting.

Improving practicality of radiofrequency ablation for eradication of Barrett*s mucosa: a randomized trial comparing two different treatment regimens for focal ablation using the HALO90 System

To develop a simplified HALO90 ablation protocol at the same energy level and with compared efficacy and safety as the current protocol.

Antecolic versus retrocolic route of the gastroenteric anastomosis after pancreatoduodenectomy: ARCO-trial

Primary objective:To determine the relationship of route of gastroenteric anastomosis after PD and postoperative incidence of DGE.Secondary objectives:To determine the relationship of route of gastroenteric anastomosis after PD and gastric emptying…

Computer supported follow-up after curative treatment of colorectal cancer based on CEA

To increase the amount of curatively treatable metastasis and recurrences of CRCandmaking an evidence-based guideline for the use of CEA in the follow-up of CRC

Informing relatives about their cancer risk and preventive measures. A trial to assess the effectiveness of additional counseling.

The aim of this study is to evaluate an intervention aimed at improving family disclosure of inherited cancer risks by 1) supporting counselees in what they experience as a necessary, but at times difficult, task and, consequently 2) provide more at…

Prospective randomized comparison of EMR versus EMR followed by photodynamic therapy for the treatment of early barrett's cancer.

In this project we will evaluate the added value of PDT after complete EMR in patients with prior HGD and EC in Barrett*s esophagus.

Improving practicality of radiofrequency ablation for eradication of Barrett*s mucosa: a randomized trial comparing two different treatment regimens for circumferential ablation using the HALO360 System

The aim of the study is to develop a shorter, less technical demanding and therefore less uncomfortable for the patient, procedure for the HALO360 treatment of Barrett's esophagus with early neoplasie, high-grade or low-grade dysplasia, without…

Consequences of liver surgery for liver function and cell injury

1 Primary Objective To investigate the effects of 15* liver ischemia versus 30* liver ischemia on liver injury and liver function.To investigate the effect of liver manipulation during mobilisation for a right hemihepatectomy, that can be used as a…

Clip Placement Following Colonic Endoscopic Mucosal Resection (EMR). The CLIPPER Study: A nationwide multicentre randomized clinical trial.

To investigate whether prophylactic clipping (PC) after endoscopic mucosal resection (EMR) of a flat polyp in the colon prevents delayed bleeding (DB) and is cost-effective.

Minimally invasive versus open pancreato-duodenectomy for pancreatic and peri-ampullary neoplasm (DIPLOMA-2): an international multicenter patient-blinded randomized controlled trial

The aim of DIPLOMA-2 is to compare MIPD with OPD regarding post-operative complications (non-inferiority) and time to functional recovery (superiority) for pancreatic and peri-ampullary neoplasm in high-volume centers in an enhanced recovery setting…

Rapid on-site evaluation (ROSE) vs. randomly collected samples from mediastinal and abdominal lymph nodes obtained by endoscopic ultrasound-guided fine-needle-aspiration

The goal is to investigate the added value of having a cytotechnician on-site while performing EUS-FNA of a lymph node.