25 results
Study Objectives:Primary Objective* To determine the safety profile of long-term MLN0002 treatmentResource Utilization and Patient-Reported Outcome Objectives* To determine the effect of long-term MLN0002 treatment on time to major inflammatory…
Primary objectives1. What is the effect of stopping mesalazine in the maintenance setting of patients with quiescent CD?2. Can subgroups of CD patients, for example based on prior treatment (medical vs. surgical), localization of disease, disease…
To study potential abnormal functioning of the bile salt-FXR-FGF19 axis in patients with clinically quiescent Crohn*s colitis.
The aim of the study is to quantify the accuracy and cost-effectiveness of a diagnostic decision rule for OBD, in patients with persisting lower gastro-intestinal complaints in primary care.
1) Study the chemopreventive potential of 5-ASA and UDCA in UC by evaluating the effect of treatment on ACF number, size and rate of dysplasia, relative to the placebo group. 2) Gain mechanistic insight into the chemopreventive properties of 5-ASA…
To determine the composition of immune cells and the expression of immunological factors in normal squamous esophagus, RE, BE and EAC.
1. Determine the presence of lesions in the upper gastrointestinal tract in patients with a primary diagnosis of CD and UC, using endoscopy and histology, before starting medication.2. Asses the prevalence of histological lesions such as focal…
Primary Objective for the Induction Phase* To determine the effect of MLN0002 induction treatment on clinical response at 6 weeksPrimary Objective for the Maintenance Phase* To determine the effect of MLN0002 maintenance treatment on clinical…
To study potential abnormal functioning of the bile salt-FXR-FGF19 axis in patients with clinically quiescent Crohn*s colitis.
Primary Objective for the Induction Phase* To determine the effect of MLN0002 induction treatment on clinical remission at 6 weeksPrimary Objective for the Maintenance Phase* To determine the effect of MLN0002 maintenance treatment on clinical…
The effect of pregabalin treatment on patients with chronic pancreatitis
We propose to assess the accuracy of MRI in a multicenter diagnostic accuracy study that will include a consecutive series of patients from the general population with suspected acute appendicitis. Patient acceptance and cost-effectiveness will also…
The aim of the study is to assess the accuracy and feasibility of contrast enhanced ultrasonography (CE-US), in the primary diagnosis and relapse during follow up of small bowel CD, compared to MR enterography. Furthermore we attempt to determine…
1. Determine the influence of acetylcysteine on thiopuirine related hepatotoxicity2. Determine the relation between hepatotoxicity, thiopurine metabolism, amino acid availablility and markers for oxidative stress3. Determine the effect of…
The aim of this study is twofold:1. To investigate the mechanism by which the immunological response is disturbed in patients with and without mutations in the NOD2/CARD15 gene. This will provide a better insight in the downstream effects of these…
The aim of this project is to assess differential responses in immune cells derived from peripheral bloodof IBD patients concerning:Immunological phenotype in CD patients:1. defining the genotype in CD patient cohort2. production of interleukin-8…
Monitoring of serum drug levels may help to optimize dosing schedules and decrease the risk of infusion reactions and subsequent treatment failure. In the future we want to routinely measure anti-TNF levels in IBD patients that are treated with…
Assesment of small bowel CD activity using the NBI compared to the conventional white light endoscopy, using the single balloon enteroscopy system in patients with known CD and suspected small bowel disease activity.
To demonstrate and compare expression of CCL25 and CCR9+ lymphocytes in peripheral blood and colon of PSC-, PSC/IBD-, IBD-, gastroenteritis patients and controls.
PRIMARY• To investigate whether calcium supplementation, in addition to standard induction therapy, decreases intestinal permeability (Chroom EDTA) in patients with active ulcerative colitis.• To observe whether calcium supplementation, in addition…