2639 results
This is a Phase 2, open-label, multicenter trial designed to evaluate the efficacy and safety of CUDC-907 in subjects 18 years and older with RR DLBCL, including those with MYC Alterations.
Primary objective: Estimate the added value of using hydrogel in addition to clips only in terms of the Conformity Index (Cx) of tumorbed delineationSecondary objectives: Estimate the Cavity Visualisation Score (CVS), distance between the center of…
To assess the safety and tolerability and to define the dose limiting toxicities (DLT) and maximum tolerated dose (MTD) of BMS-986158 as for subjects with selected advanced solid tumors.
To assess the safety and biodistribution of 89Zr-pembrolizumab and its uptake in tumor and target irAE tissues
Evaluation of the effect of daratumumab in combination with ATRA in patients with relapsed/refractory multiple myeloma
Objective of the study is to investigate if a mild sensitizing drug (oral capecitabine) combined with a high dose hypofractionated radiation regime to the esophageal region is feasible in this unfit patient group. If feasible, in a consecutive study…
Primary Objective: • To explore the effectiveness of EMDR therapy treatment in reducing symptoms of chemotherapy-induced conditioned nausea and vomiting in (former) patients with cancer.Secondary Objective:• To explore impact on QoL of chemotherapy-…
This study aims to determine the effect of real-time symptom monitoring on HRQoL in patients with mBC who start first-line chemo(immune)therapy. Further objectives include analyzing the effect of PRS monitoring on physical functioning, the severity…
The primary objective of this study is to investigate the effect of dried chicory root (WholeFiber) during 6 weeks on fecal SCFA levels in intermediate to high-risk melanoma patients after surgical treatment with no concurrent adjuvant treatment.…
Objective is to perform a pilot study in order to assess wether a randomized controlled study can follow. This randomized study is necessary to proof effectiveness compared to regular photodynamic therapy. Objective is to present an effective and…
The aim of this trial is to investigate the safety and efficacy of an adaptive anastomosis using the C-REX RectoAid Cath following elective anterior resection for sigmoid or proximal rectal cancer, or premalignant lesions not amenable tot endoscopic…
To investigate whether TLND can be safely omitted in patients with macroscopic resectable stage III (B/C/D) melanoma achieving an MPR within the ILN upon neoadjuvant treatment with nivolumab in combination with ipilimumab.
To assess the impact of using breathing instructions while performing motion-compensated MR imaging of lesions in the thorax or abdomen aimed at radiotherapy treatment planning as compared to motion-compensated scans without instructions and free-…
Determine the safety (oncologica! outcome and toxicity) of an comprehensive treatment combining recent advances in the treatmentof high risk prostate cancer.
Primary Objective: To determine the recommended phase II dose (RP2D) of thermoradiotherapy in LA-HNSCC patients. Secondary Objective(s): • Evaluate the Local control, Disease Free Survival and Overall Survival of thermoradiotherapy. • Objective…
To develop a 5 fraction de-escalated dose SBRT protocol potentially capable of reducing side effects intended for prostate cancer patients with empty bladder
To evaluate the effect of combined PVE/HVE compared to PVE alone on resectability and overall survival in patients with primary liver cancers.
Benign liver tumors and cysts carry a significant burden on the quality of life in some cases. Apart from impairing symptoms, psychological burden might provide sufficient ground for surgical intervention. There is a variable approach to them…
The proportion of successful patients, defined as an improvement in LARS category, will be 25% larger in the experimental group than in the control group (in which 10 % improvement is assumed).