20 results
1. To validate accelerometer cut-points to asses physical activity and sedentary behavior of breast cancer survivors. 2. To investigate the validity of accelerometers, inclinometers, heart rate and oxygen consumption to assess time spent in…
The primary objective of this clinical study is to identify whether activating mutations in ESR1 detected in circulating tumor DNA (ctDNA) in peripheral blood are associated with resistance to endocrine therapy in patients with ER-positive, human…
Primary goal of this study is to establish the *healthy* immune response in SLN of patients undergoing a prophylactic mastectomy.Secondary goal is to determine the incidence of IHC-positive SLN due to *benign* epithelial cell displacement
Objective: determine whether a Likert-type scale scoring system, specified for skin irritation reactions (erythema, itching, burning sensation of skin and general irritation of skin) can function as a tool to score the radiation-induced dermatitis…
Aim of the hereby proposed study is to evaluate the DA for FP on its effectiveness compared to treatment as usual (TAU) regarding outcomes of decision making and decision making processes. Primary outcome is decisional coflict.
The aim of this project is to determine optimal communication strategies for prognostic disclosure in the palliative phase of breast cancer from a patient perspective. Study 1: To explore breast cancer survivors*, healthy women*s and oncologists*…
The primary aim of the study is to develop the Dutch version of the FCRI (Fear of Cancer Related Inventory)
Our objective is to test the feasibility and preliminary effects of a web-based patient portal containing a survivorship care plan, online questionnaires for symptoms and HRQL with personalized feedback and a physical activity support programme that…
A) Follow-up of breast cancer patientsPrimary research question1.In the follow-up of breast cancer patients: does a group medical consultation (GMC) increase patient empowerment compared to a regular individual visit and/or does it decrease…
The principle aim of this study is to characterise all of the genetic alterations that are present in different types of breastcancer by comparing the cancer genome to it's matched normal genome.The primary goals of this ICGC project, which…
To evaluate the effect of HSP90 inhibition by AUY922 on VEGF by means of 89Zr-bevacizumab PET. Primary endpoint: measurement of decreased VEGF compared to baseline. A decline is defined as a decrease of at least 30% in mean Standardized Uptake Value…
The aim of this study is to evaluate patients and surgeons aesthetic satisfaction and to assess the impact on self-esteem with immediate breast reconstruction using DIEP- flap procedure.
To study motivational and psychological aspects, aestetic outcome, and general satisfaction in two groups of women who opt for mastectomy with breast reconstruction either with autologous material using the DIEP-flap procedure or with silicon…
To study the neuroplasticity of the brain after mastectomy and breast reconstructive surgery by assessing the somatotopy of the breast on the somatosensory cortex of patients who underwent either breast reconstruction with and without nerve…
The primary objective is to identify the relevant domains of health-related quality of life as experienced by patients who are previously treated with neoadjuvant chemotherapy for HER2-positive breast cancer. Secondary Objectives: * To adjust…
To determine the difference in change over time of cognitive function and brain magnetic resonance imaging (MRI) measurements between breast cancer survivors and cancer-free individuals.
To determine the the impact of 30% daily caloric restriction or daily exercise training on tumor and muscle tissue protein synthesis rates in breast cancer patients.
The value of implementation and cost-efficacy of Tumor Volume / Breast Volume Ratio, as measured by Automated Breast Volume Scanner (ABVS), during the preoperative workup in breast cancer patients on 1) cosmetic result after BCS, and 2) surgical…
To evaluate the effects of COS with tamoxifen or letrozole compared to standard COS, on oocytes retrieved.
Our primary objective is to test the feasibility of a tailored physical therapy program especially designed for metastatic breast cancer patients. As a secondary objective we will evaluate the impact of the program with regard to goal attainment,…