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Adrenal vein sampling as a tool to identify biomarkers that aid the diagnosis of adrenocortical carcinoma

To detect differences between ACC patients and controls without ACC, and between the diseased and healthy adrenal gland of ACC patients, in microRNA (miRNA), circulating cell-free tumor DNA (ctDNA), circulating tumor cells (CTCs), and steroid…

Precision Radiotherapy using MR-linac for Pancreatic Neuroendocrine Tumours in MEN1 patients

This project aims to explore the efficacy and safety of radiotherapy for asymptomatic pNET using delivery of radiotherapy by MR-linac in Multiple Endocrine Neoplasia 1 (MEN1) patients.

Reduction of complications for head and neck cancer: Individual lymph node irradiation (iNode)

In the iNode project we want to show it is technically possible to irradiate individual lymph nodes. For this reason, we will treat 20 patients with laryngeal, hypopharyngeal or oropharyngeal cancer with radiation. The radiation dose will be applied…

Phase 1b/3 global, randomized, controlled, open-label trial comparing treatment with RYZ101 to standard of care (SoC) therapy in subjects with inoperable, advanced, somatostatin receptor expressing (SSTR+), well-differentiated gastro-enteropancreatic neuroendocrine tumors (GEP-NETs) that have progressed following prior 177Lu-labelled somatostatin analogue (177Lu-SSA) therapy (ACTION-1)

This study has been transitioned to CTIS with ID 2023-509334-19-00 check the CTIS register for the current data. This study aims to determine the safety, pharmacokinetics (PK) and recommended Phase 3 dose (RP3D) of RYZ101 in Part 1, and the safety,…

Percutaneous intratumoural holmium microspheres brachytherapy for patients with pancreatic cancer;
a single centre, prospective safety and feasibility study

To test the feasibility and safety of minimally invasive CT-guided percutaneous holmium-166 microsphere brachytherapy in patients suffering from irresectable pancreatic cancer.

Trained immunity of myeloid cells and their progenitors in patients with non-medullary thyroid carcinoma, colon carcinoma and melanoma

To assess the transcriptional, epigenetic and functional reprogramming of circulating monocytes and BM myeloid progenitor cells in TC, CC and melanoma before and after in vitro exposure to agents that induce trained immunity.

Neo- and adjuvant targeted therapy in BRAF-mutated anaplastic cancer of the thyroid

This study has been transitioned to CTIS with ID 2024-516126-54-00 check the CTIS register for the current data. The main objective of this study is to study the feasibility and efficacy of neo-adjuvant treatment with BRAF/MEK inhibition to increase…

Biomarker identification of radionuclide therapy-induced radiation responses.

This is a pilot study to validate the possibility of determining the effect of PRRT with 177Lu-DOTATATE on transcriptional regulation and DNA damage induction in PBMCs and how this is related to the radiation dose.We will also want to explore if we…