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Generation of urothelial cancer organoids to investigate tumor biology in organoids and to perform drug sensitivity testing.

Primary objective:To establish and propagate a bladder cancer / immune cell co-culture model to study patient response to immunotherapy ex vivo. (Can organoid and immune cell co-cultures be maintained for 3 passages?) Protocols will be improved…

National PROspective infrastructure for Renal Cell Carcinoma

To set up a prospective, nationwide infrastructure that identifies and follows patients diagnosed with RCC and mRCC over time. This infrastructure will:• evaluate oncological and functional outcomes for patients diagnosed with RCC;• evaluate the…

Safely reduce cystoscopic evaluations for microscopic Hematuria patients (SeARCH Trial).

To assess the clinical impact of implementing a molecular urine test in the diagnostic workup of patients presenting with microscopic hematuria.

A Phase IIB, Open Label, Study of Zirconium Zr 89 Crefmirlimab Berdoxam PET-CT in Subjects with Selected Advanced or Metastatic Malignancies including Melanoma, Merkel Cell, Renal Cell and Non-Small Cell Lung Cancers, Scheduled to Receive Standard-of-Care Immunotherapy (IOT) as a Single Agent or Combination, to Predict Response to Therapy

Primary objective: evaluate the performance of zirconium Zr 89 crefmirlimab berdoxam PET-CT for predicting patient response to immunotherapy. Secondary objectives: - evaluate the performance of zirconium Zr 89 crefmirlimab berdoxam PET-CT for…

A Phase 2, Open-Label, Multi-Center, Randomized Study of TAR-200 in Combination with Cetrelimab and Cetrelimab Alone in Participants with Muscle-Invasive Urothelial Carcinoma of the Bladder who are Scheduled for Radical Cystectomy and are Ineligible for or Refusing Platinum-Based Neoadjuvant Chemotherapy

This study has been transitioned to CTIS with ID 2023-507189-17-00 check the CTIS register for the current data. 2. Objective of the study (in English): The main purpose of this study is to determine the anti-tumor effects of TAR-200 + IV cetrelimab…

EffectiveNess of a multimodal preHAbilitation program in patieNts with bladder canCEr undergoing cystectomy. The ENHANCE randomized controlled trial.

To study the effectiveness of a multimodal prehabilitation program preceding radical cystectomy in reducing the number and severity of perioperative complications within 90 days, shortening the length of hospitalization and reducing the number of…

The pharmacological effects of using cabozantinib with a light breakfast

The primary is to investigate to the change in exposure to cabozantinib by taking cabozantinib with a light breakfast compared to taking cabozantinib in fasted state. The secondary objectives are to investigate the analytical feasibility of…

CHemotherapy And Sequential ImmunoTherapy for locally advanced urothelial cancer: the CHASIT study

This study has been transitioned to CTIS with ID 2024-516940-24-00 check the CTIS register for the current data. To demonstrate the benefit of sequential chemo-immunotherapy in increasing the proportion of patients reaching a pathological complete…

A first step towards ultra-hypofractionation for unfavourable intermediate and high-risk prostate cancer: a prospective safety and feasibility study in patients with metastatic prostate cancer

to take a first step towards ultrahypofractionation for high-risk prostate cancer by showing the technical feasibility of PTV-margin reduction around the SV using adaptive radiotherapy. Primary: To assess the feasibility of reducing the PTV-margins…