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Perceptual learning to reduce crowding in visually impaired children: 'Learning to see the forest ánd the trees'

The main goal of this study is to investigate whether visual perceptual learning, i.e. practicing a challenging visual task and thereby improving performance, transfers to improved reading and search performance in children with visual impairment.…

Partial endothelial trepanation in addition to deep anterior lamellar keratoplasty in keratoconus patients. A randomized clinical trial.

To investigate the additional value of partial endothelial trepanation (PET) in a deep anterior lamellar keratoplasty (DALK) procedure in terms of efficacy and safety in patients with keratoconus.

Intraocular straylight in patients with retinitis pigmentosa.

To determine the prevalence of disability glare in RP patientsTo identify the origin(s) of disability glare in RP patientsTo establish the clinical value of straylight measurements in RP patients

Development of the infant eye following congenital and traumatic unilateral cataract.

Measurement of the growth of the eye of children with unilateral cataract.

Long-term effects of the crowding training and transfer to untrained tasks

• Determine to which extent near visual acuity and crowding improvements are retained at 6 and 12 months after training • Determine transfer of training effects to untrained tasks, in this case reading and fine motor performance.

A Phase 2, Randomized Placebo-Controlled, Double-Masked Study to Assess Safety and Efficacy of Multiple doses of IONIS-FB-LRX, an Antisense Inhibitor of Complement Factor B, in Patients with Geographic Atrophy Secondary to Age-Related Macular Degeneration (AMD)

To evaluate the effect of ISIS 696844 on the rate of change of the area of GA secondary to AMD measured by fundus autofluorescence (FAF)

Phase 3 Randomized, Controlled Study of AAV5-hRKp.RPGR for the Treatment of X-linked Retinitis Pigmentosa Associated with Variants in the RPGR gene

Primary:To assess the effect of bilateral treatment with AAV5-hRKp.RPGR on functional vision as measured by vision-guided mobility assessment.Secondary:To assess changes after treatment administration in retinal function, functional vision, visual…

Prospective study on safety and efficacy of gene therapy with voretigene neparvovec (Luxturna®) in patients with RPE65-associated inherited retinal degenerations

To collect long-term, real world data on safety and efficacy of gene therapy with voretigene neparvovec (Luxturna®).

Connection Interrupted: Genetic causes and clinical characteristics of hereditary optic neuropathies

The goal of this study is to identify the genetic causes underlying hereditary optic neuropathies and establish genotype-phenotype correlations. This will lead to more reliable prognosis predictions, better genetic counselling and hopefully form a…

A Double-Masked, Randomized, Controlled, Multiple-Dose Study to Evaluate the Efficacy, Safety, Tolerability and Systemic Exposure of QR-110 in Subjects with Leber*s Congenital Amaurosis (LCA) due to c.2991+1655A>G Mutation (p.Cys998X) in the CEP290 Gene

Primary: To evaluate the efficacy of QR-110 administered by intravitreal (IVT) injection.Secondary:1. To evaluate the safety and tolerability of QR-110 administered via IVT injection.2. To evaluate changes in patient-reported outcome (PRO) measures…

Phase 3 Follow-up Study of AAV5-hRKp.RPGR for the Treatment of X-linked Retinitis Pigmentosa Associated with Variants in the RPGR gene

This study has been transitioned to CTIS with ID 2024-511411-25-00 check the CTIS register for the current data. Main objective:To assess the long-term safety and tolerability of AAV5-hRKp.RPGR in individuals with RPGR-XLRPTo assess the long-term…

A Double-Masked, Randomized, Controlled, Multiple-Dose Study to Evaluate the Efficacy, Safety and Tolerability of QR-421a in Subjects with Retinitis Pigmentosa (RP) due to Mutations in Exon 13 of the USH2A Gene with Advanced Vision Loss

Primary • To evaluate the efficacy of QR-421aSecondary• To evaluate the safety and tolerability of QR-421a • To evaluate changes in Patient-Reported Outcome (PRO) measures in subjects treated with QR-421a• To evaluate systemic exposure of QR-421a

*Project *PLING*: development of a home-based app which uses Perceptual Learning to improve vison in children with Infantile NystaGmus*

The first goal of the PLING-project is to improve the clinical applicability of the training by developing a home-based app that can be on any Windows or Mac system. The second goal is to optimize training gain by: 1) increasing the number of…