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Standard versus transepithelial corneal crosslinking for treatment of progressive keratoconus

To evaluate the role of the epithelium in the effect of CXL for treatment of progressive KC and to determine whether the epithelium should be removed or can be left intact during treatment.

A PROSPECTIVE MULTICENTER CLINICAL TRIAL TO EVALUATE THE SAFETY AND
EFFECTIVENESS OF THE ACUFOCUS* CORNEAL INLAY ACI 7000PDT IMPLANTED
INTRA-STROMALLY FOR MODIFIED MONOVISION IN PRESBYOPIC SUBJECTS

The objective of this study is to evaluate the safety of the AcuFocusTM ACI 7000PDT corneal inlay implanted intra-stromally in emmetropic presbyopes and the effectiveness of the inlay for improvement of near vision.

A phase I, open-label study to investigate the absorption, metabolism, excretion, and mass balance of [14C]QLT091001 following single oral dose in healthy male subjects

The study objectives are:- to characterize the biotransformation pathways, the routes and rates of excretion, and total recovery of the 14C-labeled research medication and its radiolabeled metabolites- to characterize the pharmacokinetics (PK) of…

Prospective clinical evaluation of Stargardt disease patients with the
appropriate genotype for development of antisense oligonucleotide therapy

The goal of this study is to characterize the natural history of STGD1 patients with the appropriate genotype for AON therapy and to identify the best clinical outcomes to measure therapeutic efficacy in clinical trials following completion of this…

A phase 3, open-label, multicenter, extension study to evaluate the long-term safety and efficacy of Pegcetacoplan in subjects with geographic atrophy secondary to age-related macular degeneration

This study has been transitioned to CTIS with ID 2024-512945-18-00 check the CTIS register for the current data. Objectives:Primary: To evaluate the long-term safety of IVT injected pegcetacoplanSecondary:1. To assess changes in the total area of…

Methylprednisolon Pulse Therapy vs Methylprednisolon Pulse Therapy combined with Radiotherapy for Moderately Severe and Active Graves* Orbitopathy

In this study, we want to demonstrate that MPP is no less effective than MPP plus XRT.