18 results
To evaluate the safety and efficacy of abicipar (2 mg), compared to 0.5 mg ranibizumab in treatment-naïve patients with neovascular AMD.
To evaluate the role of the epithelium in the effect of CXL for treatment of progressive KC and to determine whether the epithelium should be removed or can be left intact during treatment.
The objective of this study is to evaluate the safety of the AcuFocusTM ACI 7000PDT corneal inlay implanted intra-stromally in emmetropic presbyopes and the effectiveness of the inlay for improvement of near vision.
The study objectives are:- to characterize the biotransformation pathways, the routes and rates of excretion, and total recovery of the 14C-labeled research medication and its radiolabeled metabolites- to characterize the pharmacokinetics (PK) of…
Primary: to evaluate the effectiveness of two treatment regimens by assessing the average stable maximum best-corrected (BCVA) change from Month 4 to Month 12 compared to Month 3. A treatment regimen will be considered a relevant treatment option if…
Evaluation of pre-operative parameters in order to ascertain the need for a keratoplasty after cataract surgery has been performed in eyes with Fuchs* endothelial dystrophy.
Our research proposal has several aims: 1) We propose to use large-scale genetic studies to identify allelic variants that influence the development of AMD, which will enable the development of diagnostic and prognostic tools in the near future. 2)…
Primary objectiveTo assess the efficacy of intravitreally (ITV) administered VEGF Trap-Eye compared to ranibizumab (in a non-inferiority paradigm) in preventing moderate vision loss in subjects with all subtypes of neovascular AMD Secondary…
To investigate if there is an association with the R142W mutation in the RDS gene in a group of dry AMD patients from the North Limburg region
The aim of this study is to use different non-invasieve techniques to measure the spatial distribution of the macular pigment and its possibly relation with retinal structure and contrast sensitivity.
The goal of this study is to characterize the natural history of STGD1 patients with the appropriate genotype for AON therapy and to identify the best clinical outcomes to measure therapeutic efficacy in clinical trials following completion of this…
To investigate whether mutations in genes associated with lipid metabolism are a risk factor for retinal pathology such as the early formation of drusen
Primary To evaluate the efficacy of Pegcetacoplan compared to sham injection in patients with GA secondary to AMD assessed by change in the total area of GA lesions from baseline as measured by FAF.Key SecondaryTo evaluate the efficacy of…
This study has been transitioned to CTIS with ID 2024-513483-26-00 check the CTIS register for the current data. To assesses the efficacy of Tinlarebant in slowing the rate of growth of atrophic lesion(s) in adolescent subjects with STGD1.
This study has been transitioned to CTIS with ID 2024-512945-18-00 check the CTIS register for the current data. Objectives:Primary: To evaluate the long-term safety of IVT injected pegcetacoplanSecondary:1. To assess changes in the total area of…
To compare miLOOP assisted cataract surgery and conventional surgery with respect to the energy needed for phacoemulsification and loss of corneal endothelial cells.
In this study, we want to demonstrate that MPP is no less effective than MPP plus XRT.
Primary:• To demonstrate that RTH258 6 mg is not inferior to aflibercept 2 mg with respect to the change in best-corrected visual acuity (BCVA) from Baseline to Week 48Secondary:• To demonstrate that RTH258 6 mg is not inferior to aflibercept 2 mg…