19 results
Primary aim:In recently traumatized individuals (at the latest on day ten post trauma exposure) with a high initial level of distress, we aim to assess the effectiveness of intranasal OT in preventing symptoms of PTSD at one months post intervention…
Primary objectives: 1. To translate and adapt the iCBT program TELLUS for use in IFRC humanitarian aid workers2. To determine feasibility of TELLUS in terms of: completion rates and self-reported treatment credibility/ expectancySecondary objective:…
In this functional Magnetic Resonance Imaging (fMRI) study, the primary objective is to examine the acute effects of intranasal OT administration on emotional- and reward-related brain processes in PTSD patients compared to traumatized healthy…
The main objective of this study is to assess the efficiency of oxytocin compared to placebo as an addition to the exposure sessions in the treatment of PTSD. We hypothesize that adding oxytocin to exposure in TF-CBT produces acute changes in…
The main objective of the study is to determine whether, and if so, to what extent, there are differences in memory vividness, detail and certainty between OCD patients, another anxiety disorder patients and healthy subjects in a repetitive checking…
The aim of this pilot-study is to establish the potential efficacy of acute doses of 50 mgs D-cycloserine (DCS), a partial NMDA agonist, in accelerating and/or augmenting the effect of exposure and response prevention (ERP) in the treatment of…
The aim of the present study is to examine whether the positive interpretive training has an therapeutic effect in patients with an anxiety disorder.
This study aims to evaluate the safety, tolerability and sedative proporties of a single dose of intransally administered dexmedetomidine in person odler than 65 years, differentiating between person using beta-blocking medication and those not…
To demonstrate non-inferiority of conscious sedation with intranasal dexmedetomidine for performing dental care in patients with intellectual disability and dentophobia.
This study has been transitioned to CTIS with ID 2024-514783-78-00 check the CTIS register for the current data. The aim of this project is to investigate CBD as a new medicine to target the ECS in the reduction of anxiety symptoms. Subsidiary aims…
Primary objective: Our key objective is to determine if a cannabinoid manipulation is more effective than a glucocorticoid manipulation to facilitate fear memory extinction retention in an experimental model of exposure therapy in healthy…
The primary aim of this study is to study the effectiveness of online CT+EMDR (vs. waitlist controls), in terms of reduction in PTSD and depression symptom-levels, for people who have been involved in a traffic accident. We expect that people…
To evaluate the acceptability and effectiveness of a deepfake victim-perpetrator confrontation in young adults with sexual violence-related PTSD.
The project evaluates an intervention aimed at arousal regulation.The research questions are:- Is there an improvement in signaling body signals and in arousal regulation after following this program?- Does this also lead to positive changes in…
The aim of this this study, is to test whether EMDR therapy, relative to a baseline phase, results in: 1) less social anxiety symptoms, and 2) less social avoidance symptoms
To investigate whether augmentation of one standardized exposure session for SAD with tVNS results in lower fear compared to expsoure plus sham. We also aim to test if tVNS yields enhanced retention of extinction memory, during a second exposure…
Our goal is to investigate the effect of EMDR treatment on abdominal pain in patiënts with Irritable Bowel Syndrome. In addition we will investigate the effect of EMDR treatment on other IBS physical complaints and on patients' experienced…
Objective: To investigate the feasibility and acceptability of the online cognitive behavioral therapy program (eHealth CF-CGT), so that the program can be tailored to the needs of the patient
The goal of the study is to examine whether optimal exposure is more effective than CBT as usual in youth with anxiety disorders. The secondary objective is to investigate whether decreases in harm expectancies are predictive of treatment outcome,…