33 results
To assess the association between baseline blood pressure and change in neurocognitive functioning after four years, and to assess whether baseline MRI phenotypes are predictive for changes in neurocognitive functioning after four years in the DANTE…
Objectives: 1. To assess the prevalence of pain in elderly with dementia and to study the relationship between the various subtypes of dementia and the presence of specific types of pain(e.g. nociceptive pain, neuropathic pain, and orofacial pain).…
The objectives of this study are as follows:1) To determine the sensitivity and reproducibility of novel assays developed at the Janssen Prevention Center to detect anti-tau immune responses in the blood of individuals.2) To determine the…
To assess whether temporary discontinuation of antihypertensive therapy in mildly cognitively impaired older patients on antihypertensive treatment improves cognitive and psychological functioning.
The primary objective is to examine the relationships between the cognitive tests results of the neuropsychological assessment and dual-task cost in elderly with cognitive impairment. The second objective is to examine differences in gait…
Our aim is to determine the effect of APO* on activity and volume of the hippocampus, a core structure of Alzheimer pathology, at a young age. Specifically, we aim 1) to determine the effects of APOE e4 on hippocampal activation in the young general…
Investigate the degree of association between the level of AGE*s and the development and progression of paratonia in Alzheimer*s Disease (AD).Research questions are:(1) Are elevated levels of AGE*s, at baseline and during 12 months follow-up,…
RationaleSince gamma band activity is thought to be an important mechanism in perceptual binding and cognitive function, interest in changes in gamma band activity in neuropsychiatric disorders has grown rapidly. Changes in gamma band oscillations…
The main objective of this project is to study the relationship between dopaminergic mechanisms and apathy in dementia. The related question, both theoretically and of direct relevance for daily practice, is whether patients with dementia are…
Primary:1. Which outcome variables of oculomotor performance and eye-hand coordinatio are useful to distinguish between Dementia with Lewy bodies, Alzheimerdementia and Parkinsondementia.Secundary:1. What are the base line values for the parameters…
investigate who is at risk and to discover possible contributing factors of the development of paratonia in different dementing illnesses
Objective: to provide an answer to the following question: in patients with AD, does treatment with a ChEI improve cerebral autoregulation?
The objective of the current study proposal is therefore to investigate *the origin of cerebral small vessel disease*
Determine the reliability, validity and the sensitivity to change of the MYOTON Handheld Digital Palpation Device for measuring the severity of paratonia in patients with dementia and paratonia .Research questions are:(1) What is the validity of the…
Primary Objectives: • To continue observational data collection for the main clinical outcomes of the research subjects who participated in the preDIVA trial between 2006-2015.• To assess the effects of long-term vascular risk factor modification on…
Our objective is to use magnetic resonance imaging (MRI) to investigate the neural changes after repeated transcranial direct current stimulation during an episodic memory task in patients with mild cognitive impairment and in healthy age-matched…
The main objectives are to understand how clinical markers and biomarkers previously identified in younger and older AD cohorts apply to the extreme elderly (90+ years old) and to identify novel biomarkers linked with resilience to developing…
This study has been transitioned to CTIS with ID 2024-517636-22-00 check the CTIS register for the current data. The main objective of the present study is to investigate the association between in vivo regional synaptic loss ([18F]SynVesT-1 PET),…
The main objective of the study is to investigate MEG-based hippocampal and whole brain neuronal hyperactivity in preclinical DIAD mutation carriers and to find proof-of-concept for the translatability of findings from preclinical AD mouse models to…
The objective of this study is to relate different vascular phenotypes, based on macro- and microvascular measurements, to changes in cognitive and physical functioning in a geriatric population.