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Wrist repair in severe trauma (WRIST) study

The objective of this study is to investigate whether reconstruction of the radiocarpal joint by implantation of a tailor-made and patient specific 3D printed interpositional arthroplasty made out of Bionate® II 80A PCU (DSM®) is feasible as a…

A multi center, multi national, open label, extension study to evaluate the long-term efficacy and safety of BMN 044 (PRO044) in subjects with Duchenne muscular dystrophy

The aim of this study is to provide continuing access to BMN 044 treatment for subjects previously treated with the study drug. The information gained from this study is expected to further characterize the efficacy and safety of BMN 044 over a…

An open-label extension study of the long-term safety, tolerability and efficacy of drisapersen in subjects with Duchenne Muscular Dystrophy.

The purpose of this study is to assess the safety, tolerability and efficacy of long term drisapersen in subjects with DMD.

Sports-related Long-term outcomes of Overuse of the Wrist

The aim of this study is to evaluate the long-term imaging and functional outcomes of overuse injuries of the wrist in (former) athletes.

Muscle relaxation properties in myopathies with positive muscle phenomena: a study using transcranial magnetic stimulation

To quantify muscle relaxation properties of fingerflexors using transcranial magnetic stimulation in patients with different myopathies to develop a screening diagnostic tool to assess who does (not) suffer from an underlying myopathy.

Gait retraining by real-time feedback in patients with knee osteoarthritis
(KneeMo Feedback Study )

A) To evaluate the use of real-time visual and audio feedback on the knee adduction moment and on kinematic patterns during gait in patients with knee osteoarthritis to decrease the biomechanical load on the knee via implicit learning and explicit…

An Open-Label Extension Study to Evaluate the Long-Term Safety, Tolerability, Biological Activity, and Systemic Exposure of ATYR1940 in Adult Patients with Facioscapulohumeral Muscular Dystrophy (FSHD)

The objectives of this study are to:• Evaluate the safety, tolerability, and immunogenicity of long-term treatment with intravenous (IV) ATYR1940 in adult patients with facioscapulohumeral muscular dystrophy (FSHD) previously enrolled in clinical…

A phase IIb, open-label study to assess the efficacy, safety, pharmacodynamics and pharmacokinetics of multiple subcutaneous doses of BMN 045 (previously known as PRO045) in subjects with Duchenne muscular dystrophy

Primary objective:To assess the efficacy of BMN 045 after 48 weeks treatment in ambulant subjects with Duchenne muscular dystrophy.Secondary objectives:To assess the safety and tolerability of BMN 045 after 48 weeks of treatment in all study…

Study to identify the genetic variations associated with phantom limb pain

The primary goals of this study are to: i. Identify genetic variations responsible for PLP across the whole genomeMore than 90% of SNPs are found in introns or intergenic regions and most of them are probably of little functional consequence.…

Cervical radicular pain: A randomised controlled trial comparing percutaneous plasma discectomy and anterior cervical discectomy.

The aim of this study is to compare the effects of anterior cervical discectomy versus percutaneous plasma discectomy on pain, on global perceived effect, functional status and health-related quality of life in a group of patients with cervical…

Asymptomatic gout in patients with severe renal failure measured by Dual Energy CT (DECT) and Ultrasonography.

to determine the percentage of patients with CKD, without a history of gout or attacks of arthritis, that have tophi measured by US,DECT and clinical examination. to determine the percentage of patients with CKD, that have tophi measured by US, and…

Volar Internal Plate Fixation versus Plaster in Extra-articular distal Radial fractures (VIPER)

To compare the functional outcome of ORIF with a volar locking plate to closed reduction and plaster immobilisation in patients with dislocated extra-articular distal radius fractures.

Ammendment of protocol: Intravenous iron treatment in iron deficient patients with idiopathic pulmonary arterial hypertension. Title amendment: Skeletal muscle strength in healthy persons and patients with pulmonary hypertension

To evaluate the effects of intravenous iron suppletion in iron deficient PAH patients.Amendment: to compare exercise capacity and isolated muscle strength in IPAH patients and healthy controls

Feasibility of MRI-imaging of the Affinis short shoulder prosthesis

To Establish the usefulness of MRI for assessment of the rotator cuff in patients with an Affinis short prosthesis implanted in the shoulder.

PRevention of knee Osteoarthritis in Overweight Females (PROOF); long-term follow-up

The aim of the current project is to evaluate the long-term effects of a) a pragmatic lifestyle intervention aimed at weight loss and b) a 30-month placebo-controlled intervention with glucosamine sulphate on the development of knee osteoarthritis…

PET imaging of arthritis by specific macrophage targeting in Rheumatoid Arthritis patients - clinical proof of concept studies

Primary aim: Stepwise feasibility study to investigate whether intravenously administered macrophage tracers [11C]DPA-713, [18F]DPA-714 and/or [18F]PEG-folate accumulate in inflamed joints of rheumatoid arthritis patients using PET(-CT).Secondary…

Undercarboxylated osteocalcin, the hypothalamic-pituitary-gonadal axis and glucose metabolism in male patients with osteoporosis.

The objective of the study is to study the effect of Teripratide (rhPTH 1-34) on undercarboxylated osteocalcin levels, testosterone concentrations, glucose tolerance and insulin sensitivity in male subjects with primary osteoporosis.

Treatment of the Medial Meniscus with the NUsurface® Meniscus Implant.
A Prospective, Multi-Center, Open Label, Non-randomized Study of the NUsurface® Meniscus Implant

To evaluate the safety, device-related complications, and performance of the NUsurface® meniscus implant as a device for the treatment of patients with degenerative and/or tears of the medial meniscus. .

Prospective evaluation of bone strength, physical activity, falls, subsequent fractures and mortality in patients presenting with a recent clinical fracture.

The primary objective is to assess bone structure parameters and bone strength by high resolution peripheral quantitative CT evaluation (HRpQCT) and physical activity in relation with subsequent falls, fractures and mortality in patients with a…

Cost-effectiveness of Early Surgery versus Conservative Treatment with Optional Delayed Meniscectomy in older Patients. A Randomized Controlled Trial.

The objective of this study is to evaluate the effectiveness and cost-effectiveness of surgical and conservative treatment of non-obstructive meniscal injuries in older patientsHypothesis: We assume equal improvement of physical function in both…