14 results
Primary Objective: to study the differences in CD4+ T cell subsets (Th1/Th2/Th17/Tregulatory/Tsenescent) between GCA patients and healthy controls at diagnosis and during follow up and in remission. Secondary Objective(s): - To characterize the cell…
This investigation aims to investigate connective tissue fibroblast activation in detail in the inflamed fibrotic connective tissue. By analyzing these cells in detail we hope to understand better how they are activated, so we can develop better and…
-To assess the central chemosensitivity by an carbon dioxide rebreathing test-To assess mouth occlusion pressures during the carbon dioxide rebreathing test-To study the relation between these results and the results obtained with the MRI and…
Because the pathophysiology of SSc is unknown, there is currently no treatment available to cure the disease itself, so only individual organ system complications are treated (7,8). Therefore, treatment is patient-specific and aimed at ameliorating…
The proposed project focuses on: a) implementation of an improved, standardized method for performing quantitative nailfold capillaroscopy to visualize morphological patterns and evaluate its diagnostic use in patients with (possible) CTD and…
Construction of a biobank with peripheral blood and skin biopsies from patients with SSc, to evaluate (new) antigens and/or (new) antibodies and/or RNA expression profiles and to correlate these findings with clinical parameters (i.e. disease…
The aim of our project is to develop a test that identifies FAP patients with a high risk to develop desmoids. In a recent study, a so-called wound-response gene expression signature was developed on the basis of serum stimulation of fibroblasts in…
The purpose of this study is to further unravel the genetic origin of these individual diseases and their relation at genes level.
What is the contribution of the different variations in the C1-inhibitor gene to the disease AMD?
To investigate the collagen metabolism in pelvic floor tissue, pelvic floor-derived fibroblasts, and adipose tissue stem cells in patients with and without pelvic organ prolapse (POP)
The main objective of this study is to assess effectiveness of the COVID-19 vaccinations, based on humoral (anti-coronavirus antibody) immunity, in GCA and PMR patients. Other objectives are assessing antigen-specific cellular (T-cell) immune…
To investigate the difference in number, phenotype and function of plasmacytoid dendritic cells and T cells in and between patients with SSc, LS and EF and between patients with these diseases and healthy controls / patients with psoriasis.
Primary Objective: To determine whether the wGRS is associated with recurrent DD. Secondary Objective(s): - To determine whether wGRS is associated with the severity of recurrence- To determine whether risk factors for DD are also associated with…
Finding the cause of the phenotype that resembles Marfan syndrome in a single family.