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CD4+ T cells and immune ageing; major players and predictors for disease activity in giant cell arteritis

Primary Objective: to study the differences in CD4+ T cell subsets (Th1/Th2/Th17/Tregulatory/Tsenescent) between GCA patients and healthy controls at diagnosis and during follow up and in remission. Secondary Objective(s): - To characterize the cell…

Effects of bosentan in a homogeneous population of SSc subjects with a predefined restriction of blood flow in the hands

The primary objectives are:- To demonstrate the relationship of blood flow in the hands and the extent of digital ulcera in patients with systemic scleroderma;- Evaluate the effect of bosentan on the blood flow in the hands from baseline to 12 weeks…

A pilot randomized controlled trial comparing the effect of a percutaneous and lipofilling technique in patients with a secondary Dupuytren*s contracture with standard fasciectomy surgery on convalenscence, contracture correction and recurrence rate.

To compare treatment of secondary Dupuytren*s contracture by standard limited (dermo)fasciectomy and by the modified percutaneous release combined with fat grafting. We focus specifically on return to function and if applicable to return to work (…

The treatment of recurrent inguinal hernias after posterior repair

The aim of this study is to evaluate the safety and the outcomes of laparoscopic correction of a recurrent inguinal hernia after previous repair.

Desmoid tumors in familial adenomatous polyposis; assessment of predictive markers.

The aim of our project is to develop a test that identifies FAP patients with a high risk to develop desmoids. In a recent study, a so-called wound-response gene expression signature was developed on the basis of serum stimulation of fibroblasts in…

Evaluation of a tailored psychological intervention as component of multidisciplinary treatment for patients with Systemic Sclerosis and elevated levels of distress

The aim of the present study is to evaluate the efficacy of a protocol for cognitive behavioral treatment (CBT) of psychological distress as a component of multidisciplinary treatment in SSc on psychological distress.

Drusen in hereditary angioedema patients, aged 50 years and older.

What is the contribution of the different variations in the C1-inhibitor gene to the disease AMD?

Dose Reduction of preoperative radiotherapy in myxoid liposarcoma

To study the feasibility of reducing the dose of preoperative radiotherapy in MLS from 50Gy to 36Gy while maintaining comparable clinicopathological responses.