58 results
The aim of our project is to develop a test that identifies FAP patients with a high risk to develop desmoids. In a recent study, a so-called wound-response gene expression signature was developed on the basis of serum stimulation of fibroblasts in…
The aim of the present study is to evaluate the efficacy of a protocol for cognitive behavioral treatment (CBT) of psychological distress as a component of multidisciplinary treatment in SSc on psychological distress.
HypothesisSexual function in female systemic sclerosis patients is impaired as a result of fibrosis of the genital tract, fatigue, chronic pain, Raynaud*s phenomenon and contractures. AimThe aim of the study is to investigate sexual function and its…
The first objective is to evaluate the safety of cetuximab in patients with scleroderma associated PAH. The secondary objective is to assess efficacy.
The purpose of this study is to further unravel the genetic origin of these individual diseases and their relation at genes level.
The objective of this study is to compare short- and long-term surgical and clinical outcomes of patients with chronic neck pain and neck disability due to a single-level spinal disorder that undergo Anterior Cervical Discectomy followed by…
What is the contribution of the different variations in the C1-inhibitor gene to the disease AMD?
To compare treatment of primary Dupuytren*s contracture by standard limited (dermo)fasciectomy and by the modified percutaneous release combined with fat grafting. We focus specifically on return to function and if applicable to return to work (…
Using AGW gives a good fixation of the polypropylene mesh in hernia inguinalis surgery and will not lead to a higher recurrence rate. The maximum acceptable recurrence rate is 10% after 3 months.
Aim of this study is measuring the effects of locoregional anaesthesia in EDS patients and comparing these effects with those in a healthy control group. The results of this study can be used to make a more valid choice for the type of anaesthesia…
The primary objective of this study is to assess whether tacrolimus is effective for the treatment of morphea.
To investigate the collagen metabolism in pelvic floor tissue, pelvic floor-derived fibroblasts, and adipose tissue stem cells in patients with and without pelvic organ prolapse (POP)
The objective of the study is to assess whether 1) two of the questionnaires used are appropriate for this subgroup of stroke patients and 2) the combination of positioning of the hemiplegic arm with simultaneous application of electrical…
• Evaluation of the safety, tolerability and immunogenicity of subcutaneous (s.c.) administration of ACZ885 in pediatric subjects with SJIA.• Assessment of the initial efficacy profile (% responder to treatment and time to relapse) according to the…
The objective of this study is to evaluate the effect of high dose MTX on skin induration in patients with eosinophilic fasciitis. In addition, we study the effect of this treatment on joint mobility, peripheral blood eosinophilia, functional…
To evaluate clinical and esthetic outcomes and patient satisfaction following single-tooth replacement in the anterior maxilla in patients treated with a collagen matrix (Geistlich Mucograft® Seal) and a free connective tissue graft versus…
Primary Objective* To estimate the proportion of subjects who flare within 40 weeks followingwithdrawal of ETN in subjects who have achieved ASDAS CRP less than1.3 (inactive disease).Secondary Objectives* To estimate time to flare after withdrawal…
Objectives: For patients with connective tissue disease-associated pulmonary arterial hypertension (CTD-PAH) enrolled in this study, the objectives are as follows:Primary: -To assess the efficacy of bardoxolone methyl relative to placebo.Secondary…
The aim of this study is to determine the efficacy and durability of radiotherapy as treatment for patients with Ledderhose disease and to compare this to the natural course of Ledderhose disease.
The main objective of this study is to assess effectiveness of the COVID-19 vaccinations, based on humoral (anti-coronavirus antibody) immunity, in GCA and PMR patients. Other objectives are assessing antigen-specific cellular (T-cell) immune…