76 results
To investigate the impact of 7 days of bed-rest on skeletal muscle mass, strength and whole-body insulin sensitivity in healthy, young men.
The primary objective is to test the hypothesis that a protein-rich nutritional supplement (containing 45 g of dietary protein) prior to surgery acutely increases skeletal muscle and bone protein synthesis rates in older patients undergoing a hip…
1. How does muscle overloading expressed by pain effect SB characteristics?2. What SB characteristics are associated with jaw-muscle pain?3. Are SB and psychological stress contributing factors for TMD pain?
PRIMARY OBJECTIVE1. To determine the contractile strength and the (ultra)structure of single diaphragm muscle fibers of mechanically ventilated patientsSECONDARY OBJECTIVE1. To determine whether diaphragm muscle fiber weakness is part of a…
The primary objective is to study the course of muscle (fiber) atrophy in elderly males and females with a fall-related hip fracture or elective hip surgery and the influence of additional nutritional support during hospital admission. Secondary…
The primary aim of this study is to determine the effect of creatine supplementation on muscle mass loss during short-term immobilisation in healthy, young people. In addition, we aim to study the underlying mechanisms of creatine and disuse…
The objectives of this study are:1) to quantify the muscle symptoms, muscle complaints, limitations in daily living, fatigue, mood disorders, and quality of life in patients with Brody's syndrome.2) determining the genetic background of Brody…
To investigate whether twice daily local (calf muscle) NMES attenuates muscle loss during 2 weeks of unilateral ankle immobilization due to an ankle fracture.
PRIMARY OBJECTIVE:To determine the contractile strength of diaphragm fibers of COPD patients before and after in vitro exposure to CK-107. SECONDARY OBJECTIVE:To determine the contractile strength of latissimus dorsi fibers of COPD patients before…
The aim of this study is to investigate the effect of a single bout of NMES on post-prandial muscle protein accretion during the day and prior to sleep in healthy elderly males.
The primary objective is to identify (epi)genetic and environmental disease modifying factors that contribute to the variable clinical phenotype of FSHD, in order to support the future development of new treatment strategies for FSHD. The secondary…
The objective of the study is to map in a standardized way the phenotype of carriers with known LHON mutations. We want to study the natural course of persons with LHON mutations by examining patients several times. Further, we want to study a…
PRIMARY OBJECTIVE:To determine the contractile strength and the (ultra)structure of single diaphragm muscle fibers of CTEPH patients SECONDARY OBJECTIVES:1. To determine whether diaphragm muscle fiber weakness is part of a generalized muscle…
1) Determine the sarcomeric function in muscle fibers from FSHD patients2) Determine whether sarcomeric dysfunction is specific for FSHD or is part of a generalized pathology common to muscular dystrophies3) Test new therapeutic strategies (in vitro…
To fully characterize skeletal muscle strength and endurance, phenotype and muscle fiber type-specific satellite cell content in frail elderly as compared to those elderly that do not classify as frail according to clinical criteria.
The primary objective of this proof of principle study is to determine the effect of levosimendan on the strength and endurance of the diaphragm in healthy subjects. The secondary objective is to gain insight in the neural activation and efficiency…
The primary objective is to determine whether the diaphragm develops contractile fatigue during a weaning trial and if this is associated with weaning failure. Furthermore, the hypothesis whether diaphragm efficiency (Effdi = electrical activity of…
To develop a reproducible and valid method for measuring muscle power and to assess main underlying determinants, i.e. activation dynamics, fibre typing and controller function.
To investigate the effects of 5 days of one legged knee immobilization with or without daily NMES on quadriceps CSA, lean mass and muscle fiber characteristics.
Find en give answers on the following questions: If ASR does occur can this be correlated to the seriousness of the maximum partal sphincter dilatation and /or the congenital perineum length?