20 results
We aim to explore the role of PFM activity in male LUTS
Primary:* To assess the long-term safety of idebenone in DMD patients who completed the SIDEROS study.Secondary:* To describe the long-term evolution of respiratory function in idebenone-treated DMD patients who completed the SIDEROS study,…
We aim at investigating the interplay between DUX4 and inflammation in FSHD combining MRI imaging, histology, gene and cytokine expression.
To determine the relationships between respiratory function, secretion management, RTIs and mortality in order to optimize medical decision-making.
The aim of this Eat well, Move well intervention is to study the effect (in addition to DOW) on physical performance, nutritional status, delaying or preventing institutionalization, number of falls, and quality of life of frail older adults with…
Objective of the validation study is evaluating the optimal imaging modality, diffusion tensor magnetic resonance imaging (DT-MRI) or ultrasound, for measuring pennation angle and fascicle length, muscle thickness, muscle volume and cross sectional…
The primary aim of this study is to investigate the feasibility of using UTC to detect differences in proximal hamstring tendon structure between individuals with and without clinically diagnosed PHT. A secondary aim is to: 1) investigate the within…
The objective of this study is to investigate the effect of BWSTT in critically ill patients on time to independent functional ambulation as compared to usual care.
This study aims to assess metabolism in patients with DM1, in resting state, in the normal situation and during exercise, taking into account muscle mass, and compared to healthy age- and gender-matched subjects. We hypothesize that DM1 is…
The primary objective of the present study is to establish the histological effects of givinostat versus placebo administered over 12 months. The secondary objectives of this study are the following: - To establish the macroscopic muscle effects of…
The primary aim of the study is to compare the effects of protein versus placebo supplementation on 24 hour post-race delayed onset muscle soreness after strenuous endurance exercise performance among endurance runners.The secondary aim of the study…
Primary Objective:The primary objective of this study is to provide confirmatory data on the beneficial effect of 2.0 g/kg of Octagam 10% given every 4 weeks compared with placebo in subjects with active DM based on the percentage of responders at…
Primary Objective: To determine the effects of balance training on the neural control of standing sway in healthy younger and older adults and see if the learned balance skills are retained. Secondary Objective: To determine if balance improvements…
The aim of this study is to guide European PH-centers to become specialized centers for training in PH. This approach is in line with European PH-guidelines [12] which classified the exercise training in specialized centers with a closely monitored…
1. Inventory of the current care of boys/men with Duchenne Muscular Dystrophy in the Netherlands: To establish the extent of implementation of the international guidelines and its updates in the Netherlands and to explore the relationship between…
1). Develop a model in which the electrical activity of the diaphragm (EAdi) is used to predict the transdiaphragmatic pressure (Pdi) 2) Assess to which degree this model is accurate in estimation Pdi-derived parameters (such as work of breathing…
The objective of this study is to evaluate the acute effects of PEEP on the position, length, and contractibility of the diaphragm.
We aim at investigating the role played by the innate and adaptive immune system and orienting a proper treatment. We will evaluate the percentage and features of circulating activated immune cells, cytokine production and gene expression profile…
The primary objective of this CMO application is to acquire follow-up MRI data of the skeletal muscles in FSHD patients to investigate the progression in fat infiltration and changes in muscle volume in these patients after 3-4 years, by using the…
The primary objective of this study is to measure mitochondrial capacity using NIRS in young and older healthy males in three different muscles (vastus lateralis, gastrocnemius and the tibialis anterior) to give insights on how age-related changes…