23 results
1. Explore the diagnostic value by comparing muscle volume, fatty infiltration and oedema/inflammation using qMRI in MG patients, healthy controls and MG mimics (other neuromuscular diseases and Graves* ophthalmopathy (GO) patients).2. Explore the…
Primary objectives: 1. To compare the efficacy of vamorolone administered orally at daily doses of 6.0 mg/kg over a 24-week treatment period vs. placebo in ambulant boys ages 4 to <7 years with DMD; and2. To evaluate the safety and…
The aim of this research study is to look at the effects of cheese ingestion at rest and after resistance type exercise training on muscle protein synthesis.
The main goal of our study is to determine the function of DUX4 in the human thymus by obtaining residual tissue from inevitable (incomplete) thymectomies during open heart surgery in infants. Our primary objective is to detect germline and skeletal…
Part A: Determine safety and tolerability of FTX-1821 in healthy subjects. Part B and C: Determine safety and tolerability of FTX-1821 in FSHD patients.
The goal of this study is to test the effectiveness of using the ArmAssist and Antari Homecare platform at home on upper extremity function in chronic stroke patients.Secundairy objectives are:- To evaluate the user-friendliness of the ArmAssist and…
Primary objectives* To correlate social, physical, and biometric activity of FSHD patients with the FSHD Clinical Score (Lamperti) and the Timed Up-and-Go Test.* To evaluate the feasibility and subjective burden of remote monitoring in FSHD patients…
The primary objective is to investigate the differences in mentalizing abilities between outpatients with chronic pain and a control group, consisting of outpatients with painful acute injuries or painful somatically explained conditions. The…
Primary objective: To investigate the prevalence of bruxism and TMD in PD patients through objective measurements and to identify factors associated with a higher risk of developing these symptoms.Secondary objectives: - To investigate the salivary…
The objective of this study is to test the feasibility, functionality and comfort of the AFO as an aid to regain the active RoM of the ankle joint in UMND patients with equinus foot. Results of the study will be used to further optimize the AFO…
Primary Objective• To assess the safety and tolerability of 3 single ascending dose (SAD) levels and 3 MAD levels of DYN101.Secondary Objectives• To assess the PK of SAD and MAD of DYN101.• To explore target engagement in muscle of DYN101.…
Primary:• To compare the efficacy of viltolarsen administered intravenously (IV) at weekly doses of 80 mg/kg over a 48-week treatment period vs. placebo controls in ambulant boys ages 4 to <8 years with DMD using the Time to Stand Test (…
To study the correlation between EMG values of the pelvic floor and functional outcomes of patients who has been treated for rectal cancer in the period January 2014 till December 2018.
Optimizing ultrasound parameters to enhance quantitative skeletal muscle ultrasound as diagnostic imaging technique to evaluate fatty infiltration of the supra- and infraspinatus muscle in patients with rotator cuff tears.
The primary objectives are to:1) Adapt and optimize sequences and protocols to enable acquisitions during exercise with MRI and/or surface EMG.2) Perform a study in healthy volunteers using the sequences and protocols developed in 1) to correlate MR…
Primary ObjectivesPart A- To evaluate the sensitivity of muscle velocity recovery cycles (MVRCs) to determine effects of ischemia on muscle membrane potentials- To evaluate the sensitivity of MVRCs to determine effects of mexiletine on muscle…
This study has been transitioned to CTIS with ID 2024-512736-29-00 check the CTIS register for the current data. Primary Objective1. To evaluate the safety and tolerability of long-term dosing of losmapimod tablets in subjects with FSHD1Secondary…
The phase I/IIa trial will consist of an intra-arterial injection (via catheter in femoral artery) of autologous MABs in the left lower leg of 5 m.3243A>G patients. The primary objective is assessing safety of administration of autologous…
The aim of our study is to establish the long-term course of (recovery of) respiratory muscle strength and exercise capacity in patients who have received * 48 hours of mechanical ventilation and are discharged home.
The effects of quark ingestion with or without prior exercise on muscle protein synthesis rates in young and old men.