14 results
Primary Objective: This study aims to analyze cycling gross efficiency, pedalling power symmetry, and hip, knee, ankle kinematics in adults with a transtibial amputation in different foot positions and seat heightsSecondary Objective(s): The second…
This study aims to isolate and culture myogenic stem cells called mesoangioblasts from the muscle biopsies to explore if genetic correction of LAMA2 mutations using CRISPR-Cas9 can be achieved and subsequently assess the effect in vitro, as a first…
Primary objective: To determine diaphragm thickness and thickening fraction in healthy children below or equal to 8 years of age.Secondary objective: To determine the interrater reliability of operators performing the ultra-sound
The main objective of this study is to evaluate the effect of the dynamic shoulder orthosis on the shoulder pain and glenohumeral subluxation.
To investigate the efficacy of targeted nutrient supplementation on daily physical activity level as well as generic health status in patients with moderate to very severe COPD. Additionally, we aim to disentangle the relative effect of targeted…
Aim of the study is to ascertain the order of magnitude to which ESWT may improve the performance of specific activities of daily living (ADL), measured by Goal Entertainment Scaling (GAS) in people with spinal cord injury and spasticity in the…
The primary objectives for this study are:To evaluate the preventive effect of GYM329 on disuse muscle atrophy in healthy male volunteers through changes in muscle strength following a single subcutaneous administration prior to unilateral thigh and…
We aim to investigate if aortic stiffness, measured by pulse wave velocity (PWV), is present in patients with DMD and whether treatment with ACEi reduces aortic stiffness.
Objectives:(1) To determine whether the AT can be identified in individuals with slowly progressive NMD through submaximal exercise testing with respiratory gas analysis. (2) To determine the reliability of the AT assessment in individuals with…
The goal of this study is to examine the effect of both treatment strategies on the running distance of the Cooper*s test, a part of the Defensie Conditie Proef (DCP) and on the time of a 5k march, as these are important indicators whether the…
Primary Objective: There are three primary objectives in this study. 1. To investigate the neuromuscular involvement of RYR1 related MH and rhabdomyolysis. 2. To investigate the immunological changes in subjects with RYR1 related MH and…
The objectives of the study are:* To evaluate the safety and tolerability of zilucoplan in subjects with IMNM* To evaluate the efficacy of zilucoplan in subjects with IMNM
To investigate lingual articulation and coarticulation as well as variability of speech in children with DMD, as compared to their healthy peers. This information will lead to a better understanding of how speech is impacted by DMD and will…
The primary goal is to evaluate the difference between diaphragm tissue characteristics and movement in extubated COVID-ICU patients after >72 hours of invasive mechanical ventilation compared to other ICU-patients and healthy controls.…