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Multicenter, open-label, single arm study to evaluate long-term safety, tolerability, and effectiveness of 10mg/kg olesoxime in patients with SMA

Main objective: The main objective of this open-label, single arm study is to further characterize the safety, tolerability and effectiveness profile of olesoxime in SMAThe primary safety objective for this study is as follows:To evaluate the safety…

Pre-operative protein feeding to stimulate muscle and bone synthesis in older patients undergoing elective hip surgery*

The primary objective is to test the hypothesis that a protein-rich nutritional supplement (containing 45 g of dietary protein) prior to surgery acutely increases skeletal muscle and bone protein synthesis rates in older patients undergoing a hip…

Sarcopenia and Physical fRailty IN older people: multi-componenT Treatment strategies

The primaire objective is to evaluate the effectiveness of a multicomponent intervention (MCI) programme (physical activity [PA], nutritional counselling/dietary intervention, and information & communication technology [ICT] intervention)…

Intra-subject variability in pain scoring and the consequences for analgesia treatment

In the current study we want to further explore the predictability of pre-treatment pain variability on the probability to experience pain relief. Knowledge on the understanding of individual differences in analgesic properties of a drug is of…

The association between Sleep bruxism and Temporomandibular disorder Pain

1. How does muscle overloading expressed by pain effect SB characteristics?2. What SB characteristics are associated with jaw-muscle pain?3. Are SB and psychological stress contributing factors for TMD pain?

Effect of whey protein-enriched enteral nutrition in addition to standardized exercise training on the PREServation of MUScle function in critically ill patients: a randomized controlled trial

First we want to determine whether early high protein intake, using an enteral whey protein supplement, in addition to a standardized exercise training program and standard enteral nutrition preserves: a) in vitro skeletal muscle function in…

Ventilator-Induced Diaphragm Dysfunction in ICU patients

PRIMARY OBJECTIVE1. To determine the contractile strength and the (ultra)structure of single diaphragm muscle fibers of mechanically ventilated patientsSECONDARY OBJECTIVE1. To determine whether diaphragm muscle fiber weakness is part of a…

ISA: evaluation of instrumented spasticity assessment in children and adults with spastic paresis

The primary objectives of this study are (a) to evaluate reliability and precision of an instrumented spasticity assessment device (ISA) in children with cerebral palsy and adults with spastic paresis (MS and stroke patients) and (b) to validate ISA…

Some control values for MR biomarkers of fatty infiltration and edema-like lesions in skeletal muscles of healthy volunteers - an explorative study

To obtain some control values for the MRI biomarkers for fatty infiltration and edema-like lesions in skeletal muscles of healthy volunteers.

STEADY; sustained technology for the evaluation of lumbar atrophy and dysfunction*

Using technology for improving diagnostics of non-specific lower back pain by physiotherapists

The concurrent validity of surface EMG compared to intramusculair EMG of the multifidus activity.

What is the correlation between intramuscular and surface EMG of the mm. multifidi in different clinical tests in healthy subjects and non-specific lower backpain patients?

EMG registration of the pelvic floor and pelvic floor muscle activity patterns during, abdominal, hip adductor, and gluteal muscle contractions in healthy women

To describe the EMG activity of the pelvic floor muscles (PFM) with a bi-polar EMG probe and the MAPLe and effect on the registered EMG activity with the probes in relation to the contractions of the muscles surrounding the pelvic floor. To describe…

The impact of protein supplementation to maximize the skeletal muscle adaptive response to resistance type exercise training in healthy elderly men

Primary Objective: To examine how protein supplemented after exercise and before each night of sleep augments the resistance type exercise training-induced changes in quadriceps muscle size (CSA) in healthy elderly men. Secondary Objective:…

Pelvic floor muscles in men: an explorative study

We aim to explore the role of PFM activity in male LUTS

Group rehabilitation for renal patients

The purpose of GRN-study is: 1. to determine the long-term effectiveness of a 12 weeks lasting physical exercise training program. 2. to determine the costeffectiveness of the 12 weeks lasting physical exercise training program. In aim of the GRN-…

Post-exercise recovery after dietary protein ingestion in healthy young men

To determine whether the intake of minced beef is equally effective as ingestion of a bovine milk protein beverage in stimulating post resistance exercise muscle protein synthesis rates in young men.

Identification and characterization of community-dwelling older people with sarcopenia.

The aim of this pilot study is to test the feasibility of a screeningset, to be used in a future cross-sectional study on the prevalence, characteristices and health and economic outcomes of sarcopenia in community-dwelling older people.

Incidence of pelvic floor injury after a first normal vaginal delivery in women with and without a mediolateral episiotomy (EPILEVA study)

Primary ObjectiveDifference in incidence of an avulsion injury and morphological changes of the levator ani muscle after a first normal vaginal delivery between participants with and without a mediolateral episiotomy.Secondary ObjectiveChanges in…

A Prospective Natural History Study of the Progression of Physical Impairment, Activity Limitation and Quality of Life in Duchenne Muscular Dystrophy (DMD)

•To characterize the natural history and progression of DMD to help inform the design of future studies•To capture biomarkers of safety and disease progression•To provide comparative data for the development of rare exons for which formal controlled…

A randomized, double blind, placebo controlled, multi-centre study to assess the pharmacodynamics, pharmacokinetics, safety and tolerability of BYM338 in chronic obstructive pulmonary disease patients with cachexia (CBYM338X2204)

Primary: Assess the effect of i.v. infusions of BYM338 on muscle volume of the thigh (assessed by MRI) at 4, 8, 16 and 24 weeks, compared to placebo, in COPD patients with pulmonary cachexia.Secondary: Effect on 6-minute walk test, safety and…