41 results
Are changes in cognitive functioning related to structural changes in the brain in patients with type 1 diabetes mellitus. How are these changes related to diabetic complications like duration of chronic hypoglycaemia, disease duration and presence…
The objective of this study is to develop a resistance training intervention that improves mobility and quality of life in diabetic patients. It is also our intension to achieve a better understanding of the relation between diabetic neuropathy and…
1) To assess whether galactosemia women with ovarian failure are able to produce estradiol after exogenous (normally bioactive) FSH and LH gift 2) To characterize FSH glycan structures
To optimize a safe five-day intensive intravenous insulin treatment post stroke and to assess glucose profiles in patients with stroke and HG on admission, receiving standard continues enteral tube feeding.
To quantify the impact of outpatient nurse-led prevention clinics on the risk of future clinical events in patients with symptomatic coronary artery disease.
Part 1 of the study has two objectives. Firstly, we will study the safety and tolerability of the drug after the administration of single ascending oral doses of the drug. Secondly we will study the pharmacokinetics and pharmacodynamics. This means…
To examine the safety, tolerability, and effect on glucose metabolism of metformin treatment in non-diabetic patients with TIA or minor ischemic stroke and impaired glucose tolerance.
The goal of this study is examining the acute effects of insulin on microcirculation in hypertensive insulinresistant subjects and investigate if angiotensine II influences these effects. Amendement: The goal of the amendement is to exame the…
The Municipal Health Service The Hague and the LUMC are planning to conduct a study similar to the one in Pune in The Hague. In the start-up phase of this study we are preparing a pilot study in which we will study anthropometry and insulin…
1. to investigate whether the known chronic inflammatory and hyperoxidative state in patients with severely increased LDL is associated with dysfunctional HDL.2. to investigate whether CVD in FH is associated with dysfunctional HDL.
A. To determine prevalence and determinants of impaired glucose regulation 1. To study the prevalence of impaired glucose regulation and type 2 diabetes in the general population aged 40 to 65 years, and to compare these prevalence rates with those…
Evaluation of the incidence of liver enzyme abnormalities and hepatic steatosis in all type 2 diabetes mellitus patients (about n=1500) treated at the outpatient clinic internal medicine of the St Lucas Andreas Hospital
Investigate effect of IF on insulin resistance and possible role acylcarinitin profiles and glycolipids
The central goal therefore, is to identify mechanisms contributing to an improved mitochondrial fat oxidative capacity after physical activity and consequently identify the mechanisms which are responsible for the development of clinically overt…
The application of CGMS offers novel possibilities to define the impact of different exercise parameters like exercise duration, frequency and intensity on glycemic control in type 2 diabetes patients. In addition we are interested in the impact on…
The primary objective of this study is to investigate the peri-operative accuracy and safety of the RT-CGMS in cardiac surgical patients.The secondary objective is to identify and define possible factors interfering with reliable and adequate…
Primary objective : Under conditions of first-line drug treatment in antidiabetic drug naïve/drug free patients (no antidiabetic drug treatment in the last 6 months), with type 2 diabetes mellitus and dyslipidemia, to show that : - the efficacy of a…
to determine the correlation of fetal hyperinsulinemia (measured by urine c-peptide) and maternal indicators of glucose-regulation with neonatal birth weight and postpartum glucose concentration of macrosomic infants of non-diabetic mothers
1) To determine the prevalence of MetS in the patient population of the MMIJ in IJsselstein aged 20 to 70 years2) To assess the effectiveness of population screening for MetS by general practitioners in a medium-size city in the Netherlands
The primary study objective is to investigate the contribution of peri-operative suppletion of bile to the preservation of bodyweight (expressed in kilograms).Secondary study objectives:1.To determine the contribution of peri-operative suppletion of…