40 results
There are two objectives for this study: first, to find specific serum beta cell damage markers that can serve as a clinical predictive tool for beta cell allograft loss. Second, to compare quality of life and diabetes-related outcomes in patients…
The aim of this study is to investigate the prevalence of impaired cognitive functioning in outpatients with DMT2. Second, we will investigate the relationship between impaired cognitive functions and sociodemographic factors, clinical features and…
In this study we aim to investigate the presence of CAN in diabetic patients scheduled for elective major abdominal and thoracic surgery and its relation with perioperative hemodynamic changes.
Are changes in cognitive functioning related to structural changes in the brain in patients with type 1 diabetes mellitus. How are these changes related to diabetic complications like duration of chronic hypoglycaemia, disease duration and presence…
The primary objectives are defined according to a hierarchical design: i) to tailor and apply multi-parametric, functional MRI techniques to identify cerebral abnormalities (cerebral biomarkers) in DM2 and MetS; ii) to investigate which cerebral…
Overall aimThe ultimate goal of our studies is to optimize treatment and reduce treatment related complications in patients with diabetes and cognitive impairmentOur specific objectives are to:1. assess the validity of two self-administered…
The aim of this study is to investigate if changes in vascular compliance in children with type 1 diabetes are related to endothelial markers and to changes in skin AGE and to investigate whether patients at risk to develop cardiovascular disease…
The aim of this study is to answer the question: *Will the addition of the lipoprotein profile to the conventional diagnostics for dyslipidemia in T2D patients, lead to a better risk classification of CVD development?*. The improved risk…
The primary objective of this study is to investigate whether SCS combined with best (drug) treatment as usual (TAU) leads to clinically significant (>=50%) pain relief in patients suffering from moderate-to-severe PDP in the lower limbs…
The ultimate objective is to develop an intelligent telemedicine monitoring system for early detection of (pre-signs of) ulceration in diabetic feet. The aim of the current project is to come up with a proof of principle of the modalities needed to…
1) Prevalence of celiac disease in a Dutch cohort of adult type 1 diabetes patients. 2) Investigation of the long term complications of type 1 diabetes patients with concomitant celiac disease
To investigate whether SAF is elevated in GDM versus non-diabetic pregnancy To investigate whther SAF levels change during the course of normal and GDM pregnancy To investigate if SAF is related to other parameters of hyperglycemia (HbA1c, self…
What is the incidence of a blood pressure decrease of more than 20% after spinal anesthesia in patients with diabetes mellitus type II in comparison with non-diabetics?
To evaluate whether a higher SAF level is related to a higher incidence of macrosomiaTo evaluate if a higher SAF level is related to a higher incidence of other maternal, fetal or neonatal complications To evaluate is SAF level is related to a…
1. To study the rate of change of diastolic and systolic LV function and LV structure, and the incidence of heart failure over a 7-year period in subjects with and without DM2 2. To study the potential determinants of accelerated deterioration of LV…
Assessment of the effect of kidney-pancreas transplantation in diabetic nephropathy patients on microvascular alterations using orthogonal spectral polarization and correlate this effect with markers for endothelial cell dysfunction and fibrosis
Answering the following questions:1. Are simple autonomic function tests using continuous blood pressure measurements useful to diagnose CAN at the preoperative screening? a. Are simple autonomic function tests using continuous blood pressure…
To study the effect of transient high blood glucose level on the brachial artery FMD response, and to determine the reproducibility of the measurements and observed effect.
The primary question is whether certain tubular biomarkers are associated with albuminuria. It is thougt that to much albumin in the pre-urine is toxic to the proximal tubulus. By measuring different kind of damage markers of different locations of…
Is pulse rate variability obtained from non-invasive continuous blood pressure measurements comparable to heart rate variability derived from an ECG signal during a battery of autonomic tests in healthy volunteers?