56 results
Primary Objective: 1. To determine whether there is a difference in arterial wall inflammation between well-controlled and poorly-controlled type 1 diabetes patients2. To determine whether patients with type 1 diabetes have a higher level of…
The goal of the *String-of-Pearls national academic biobank - the diabetes cohort* is to create a nation diabetes bio-databank, with DNA, urine and blood samples of 12.000 diabetespatients in combination with clinical data from the diabetes care in…
The purpose of the study is to investigate the effect of (repeated) cast immobilization on the bone strength of the lower leg in patients with diabetes mellitus. In this study, bone strength is examined by cortex thickness in millimeters and density…
The main objectives of this study is to see if changes in the innate immune system can be found in diseases associated with increased risk for atherosclerosis
The current proposal studies the efficacy of a multifactorial intervention with weight reduction, behavioural therapy, and physical exercise on the severity and control of overweight/obese children with asthma. Also the underlying mechanism of these…
1) Determine whether humanized mice develop enhanced restenosis upon vascular injury after reconstitution with human PBMCs derived from T2DM subjects with or without macrovascular disease.2) Determine what mechanism(s) induces deranged vascular…
To determine the effect of hypoglycaemia on BAT-activity.
The objectives of this study are to gain new insights on [1] the cause of a higher clopidogrel resistance in DMII patients[2] the increased production of tissue factor in monocytes in DMII patients
1) Determine differences in EPC and SMPC availability in the peripheral blood of T2DM patients with or without coronary artery disease (CAD) or peripheral artery disease (PAD) as well as in age- and sex-matched non-diabetic subjects with or without…
Aim of the Maastricht StudyThe primary objectives of the Maastricht Study are:1. to study the development of obesity, the metabolic syndrome and type 2diabetes in the general population.2. to study the development of cardiovascular disease in the…
To determine the influence of a pure sensory polyneuropathy on balance correction in light of the first trial response and in light of multiple succesive identical perturbations, compared to healthy control subjects.
To study the inflammatory response (induration) to intracutaneous Candida albicans in healthy individuals, patients with diabetes without polyneuropathy, patients with diabetic polyneuropathy and patients with a history of Charcot neuro-…
To evaluate the prevalence of advanced ovarian ageing in cycling DM-1 patients using ovarian reserve (OR) testing. To assess the mean age at natural menopause and its variation in DM-1 patients. To study the role of vascular factors in relation to…
PROVALID will have 3 major objectives:Primary: Determine the cumulative incidence of renal outcomes in patients with type II diabetes in different European countries. Renal outcomes are defined as:* Progression from normoalbuminuria to…
In the current study we will re-examine the participants of the CODAM study in a second follow-up evaluation (12 yrs after baseline) in order to obtain further longitudinal information on the natural development of type 2 diabetes and cardiovascular…
The main objective of the study is to quantify mitochondrial dysfunction in vivo and obtain information of molecular scale adaptations of the muscle cells that potentially underlie the observed dysfunction. The mathematical model will be applied to…
Primary Objective: To determine the accumulation of AGEs in the skin and serum of pregnant women with DM1, DM2 or GDM, in comparison to healthy pregnant women and non-pregnant women with DM1 or DM2 and to determine the accumulation of AGEs in the…
Aim is to establish the relation between plasma and tissue AGE levels and the severity of diastolic/vascular dysfunction and its relation with symptoms in patients with type 2 DM with and without CHF, and in patients with CHF without DM. Primary…
Primary Objective: In this study we investigate the adipose tissue depot-specific differences in adipocyte function and inflammation in patients with T2DM and subjects suffering from CVD compared to healthy subjects.Secondary Objective: Characterize…
The primary goal of this study is to te verify that it is possible to measure te concentrations of cytokines IL-1α, IL-1RA en IL-8 in the fluid of a blister that is applied tot the skin of healthy volunteers. using cantharidin. In the future we wish…