193 results
1) Prevalence of celiac disease in a Dutch cohort of adult type 1 diabetes patients. 2) Investigation of the long term complications of type 1 diabetes patients with concomitant celiac disease
The first objective is to examine the impact of 4-month walking training on physical fitness, insulin resistance and cardiovascular risks in T2DM and their controls and to assess whether these effects are preserved 3 months after cessation of the…
The objectives of this study are to gain new insights on [1] the cause of a higher clopidogrel resistance in DMII patients[2] the increased production of tissue factor in monocytes in DMII patients
The objective of the study is to be able to determine the contribution of blood inorganic phosphate to the signal observed in skeletal muscle.
1. Does general anesthesia affect autonomic sympathetic control of coronary blood flow in healthy subjects?2. Does acute inhibition of autonomic sympathetic innervation by means of a thoracic epidural or a thoracic sympathectomy additionally impair…
1) Determine differences in EPC and SMPC availability in the peripheral blood of T2DM patients with or without coronary artery disease (CAD) or peripheral artery disease (PAD) as well as in age- and sex-matched non-diabetic subjects with or without…
1) To investigate the impact of keeping/loosing diabetes on quality of life and psychological well-being in a group of (morbidly) obese patients who underwent bariatric surgery, and 2) To explore whether we can predict postoperative quality of life…
The aim of this study is to develop and evaluate a patient-oriented treatment decision aid (PTDA) focussing on shared goal-setting and decision making, which is tailored to the needs and capacities of a heterogeneous group of patients with type 2…
Aim of the Maastricht StudyThe primary objectives of the Maastricht Study are:1. to study the development of obesity, the metabolic syndrome and type 2diabetes in the general population.2. to study the development of cardiovascular disease in the…
To investigate whether SAF is elevated in GDM versus non-diabetic pregnancy To investigate whther SAF levels change during the course of normal and GDM pregnancy To investigate if SAF is related to other parameters of hyperglycemia (HbA1c, self…
To determine the influence of a pure sensory polyneuropathy on balance correction in light of the first trial response and in light of multiple succesive identical perturbations, compared to healthy control subjects.
To study the inflammatory response (induration) to intracutaneous Candida albicans in healthy individuals, patients with diabetes without polyneuropathy, patients with diabetic polyneuropathy and patients with a history of Charcot neuro-…
In this pilot study, the objective is to show an improvement in glucose tolerance,a decrease in parameters for inflammation, oxidative stress and a procoagulant state after 4 weeks of daily supplementation of L -glutamine and Epigallocatechin-3-…
To evaluate the prevalence of advanced ovarian ageing in cycling DM-1 patients using ovarian reserve (OR) testing. To assess the mean age at natural menopause and its variation in DM-1 patients. To study the role of vascular factors in relation to…
PROVALID will have 3 major objectives:Primary: Determine the cumulative incidence of renal outcomes in patients with type II diabetes in different European countries. Renal outcomes are defined as:* Progression from normoalbuminuria to…
To examine the impact of walking training on the lifetime risk for cardiovascular disease in DMT2 and DMT1 patients and to assess whether these effects are preserved 3 months after the Nijmegen 4-Day marches. Results will be compared with a control…
The objective of the study is to develop a biorepository from patients with extreme metformin intolerance to assess predictive biomarkers (clinical, genetic and genomic) of intolerance.
Are AGEs, as a predictor of increased risk for cardiometabolic syndrome, increased in shift workers?
The aim of this study is to investigate skin AGEs, as a predictor of increased risk for cardiometabolic syndrome, in a shift work population as compared to non-shift workers to assess its potential as an early assessment of the actual risk for…
The objective of the proposed study is to develop techniques for optimizing the dosage of metformin through measurement of the concentrations of the drug in plasma or red blood cells and the concentration of haemoglobin A1c in patients with diabetes…
Patients with chronic diseases require long-term adherence. Adherence can be improved by patient counseling as is common in disease management programs. However, personal counseling is expensive, especially given the fact that chronic patients will…