193 results
In the current study we will re-examine the participants of the CODAM study in a second follow-up evaluation (12 yrs after baseline) in order to obtain further longitudinal information on the natural development of type 2 diabetes and cardiovascular…
To examine whether heating can prevent the hyperglycaemia-induced decline in endothelial function in T2DM and age- and sex-matched controls.
The main objective of the study is to quantify mitochondrial dysfunction in vivo and obtain information of molecular scale adaptations of the muscle cells that potentially underlie the observed dysfunction. The mathematical model will be applied to…
The primary aim of this study is to assess the impact of prolonged walking on fluid- and electrolyte balance in 32 patients with T2DM, compared with a matched group of 32 healthy control subjects, and 32 patients with T1DM, during the Nijmegen Four…
Primary Objective: To determine the accumulation of AGEs in the skin and serum of pregnant women with DM1, DM2 or GDM, in comparison to healthy pregnant women and non-pregnant women with DM1 or DM2 and to determine the accumulation of AGEs in the…
What is the incidence of a blood pressure decrease of more than 20% after spinal anesthesia in patients with diabetes mellitus type II in comparison with non-diabetics?
Primary:To investigate the effect of VLCD (very low calorie diet) in obese patients with type 2 DM and cardiovascular complications on cardiac function, pulse wave velocity and myocardial triglyceride contentSecondary:To investigate the effect of…
The aim of this randomised, parallel study in patients with DMT2 is to investigate if the added use of skin autofluorescence to the UKPDS risk score will lead to changes in systolic blood pressure and medical treatment (primary measures of effect)…
To evaluate whether a higher SAF level is related to a higher incidence of macrosomiaTo evaluate if a higher SAF level is related to a higher incidence of other maternal, fetal or neonatal complications To evaluate is SAF level is related to a…
-Determination of the effects of an exercise program on ectopic fat accumulation in heart, liver and skeletal muscle-To assess the relationship between metabolic and inflammatory parameters with changes in MRI outcome-To assess the differences in…
To evaluate if the program *Run2gether* can change physical behavior in children with obesity and/or diabetes, and thereby increase physical fitness level and insulin sensitivity en reduce body weight. An additional goal for children with diabetes,…
The aim of this study is to investigate the effects of an intervention focussed on the communication of the absolute 10-year risk to develop cardiovascular disease on risk perception, attitude towards a specific behaviour and the intention to change…
Aim is to establish the relation between plasma and tissue AGE levels and the severity of diastolic/vascular dysfunction and its relation with symptoms in patients with type 2 DM with and without CHF, and in patients with CHF without DM. Primary…
Primary Objective: In this study we investigate the adipose tissue depot-specific differences in adipocyte function and inflammation in patients with T2DM and subjects suffering from CVD compared to healthy subjects.Secondary Objective: Characterize…
1. To study the rate of change of diastolic and systolic LV function and LV structure, and the incidence of heart failure over a 7-year period in subjects with and without DM2 2. To study the potential determinants of accelerated deterioration of LV…
The primary goal of this study is to te verify that it is possible to measure te concentrations of cytokines IL-1α, IL-1RA en IL-8 in the fluid of a blister that is applied tot the skin of healthy volunteers. using cantharidin. In the future we wish…
The primary goal of this study is to obtain basal knowledge about cytokine concentration in healthy volunteers, after pressure application. In the future we wish to use this knowledge for developing a method for:1. determining a patients risk of…
Assessment of the effect of kidney-pancreas transplantation in diabetic nephropathy patients on microvascular alterations using orthogonal spectral polarization and correlate this effect with markers for endothelial cell dysfunction and fibrosis
Identification of genetic risk factors for development of type 2 diabetes, diabetes related diseases and complications. Furthermore the examination of the relationship between genetic variation, biochemical factors, environmental factors (obesity…
To establish efficacy of pre-travel vaccinations by determination of protective serum antibody titres against hepatitis A, DTP and polysaccharide Vi of Salmonella typhi. To quantify health risks related to preventive actions and consequences of…