193 results
Primary objectives:* To assess telmisartan target (i.e. receptor) specific binding in vivo* To assess receptor occupancy of telmisartan in vivo* To determine optimal scanning time in vivoSecondary objective:* To explore the effect of telmisartan on…
To correlate platelet activity, PMV production and platelet and PMV RNA content to renal outcomes in diabetic nephropathy and to investigate the interaction between PMV and glomerular endothelial cells and podocytes.
To investigate the effects of the cognitive behavioural intervention GEXP on physical activity and quality of life, hereby targeting specific fears in patients with PDN.Hypothesis: GEXP, as addition to usual care, increases the levels of physical…
This study aims to better diagnose cardiomyopathy in the increasing high-risk populations of chronic hypertension, type two diabetes mellitus, and obesity/overweight by providing gender specific cardiac MRI cut-off values for cardiac volumes,…
The objective of this pilot study is to investigate the efficiency of a glucose monitor device placed in a tear fluid of human eye to measure glucose for up to 6 hours and its correlation to blood glucose values. Additionally, more information will…
To compare the antiproteinuric effects of sacubitril/valsartan (ARNI) and valsartan (ARB).
The objectives of our study are 1) to estimate the prevalence of LJM in patients with diabetes type 2 in The Netherlands, with a special focus on the shoulder.2) to better understand the role of diabetic neuropathy in the development of shoulder…
Decrease disease-burden in the diabetes type 2 population, by improving quality of life, physical activity levels, physical performance and the overall quality of diabetes care. Thereby empowering the diabetes population to better self-manage their…
Primary Objective • To determine whether ITCA 650 is non-inferior either to empagliflozin or to glimepiride in reducing glycosylated hemoglobin A1c (HbA1c) or weight in patients with T2D following 65 weeks of treatment. The non-inferiority margins…
To improve BP control and health related quality of life by offering a nurse-led patient-centred supportive intervention to people with T2DM who are objectively non-adherent to their antihypertensive medication and/or life style behaviour…
The objective of this pilot study is to investigate the efficiency of a glucose monitor device placed in a tear fluid of human eye to measure glucose for up to 5 hours and its correlation to blood glucose values. Additionally, more information will…
1) To study whether peri-operative haemodynamics fluctuate more in patients with DM2 and CAN. 2) To study whether CAN further worsens cerebral perfusion in addition to impaired CA.
To elucidate whether reducing glycemic variability with hybrid closed-loop therapy inhibits the inflammatory response (e.g. leukocyte phenotype, cytokine production, inflammatory proteins) in people with T1DM. Our secondary objectives are to…