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Determination of dihydropyrimidine dehydrogenase and thymidylate synthase activity in human peripheral blood mononuclear cells in healthy volunteers.

Primary objective:• To determine the range and mean population DPD and TS enzyme activity in human peripheral blood mononuclear cells in 20 healthy volunteers. Secondary objectives:• To determine the circadian rhythm of DPD and TS enzyme activity in…

PLASMA CONCENTRATION, EXCRETION AND MASS BALANCE OF ORALLY ADMINISTERED 14C-FYX-051 IN HEALTHY MALE SUBJECTS

The purpose of the study is to investigate how quickly and to what extent FYX-051 is absorbed, distributed, metabolized (converted) and eliminated from the body. The compound to be administered will be labeled with 14-Carbon (14C) and is thus…