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RCT to investigate the quality of the of endometrial sample obtained by aspiration when performed before or after the SIS in postmenopausal women.

The primary objective is to investigate the quality (whether assessable by a pathologist or not) of the endometrial sample obtained by aspiration when performed directly before or after the SIS in postmenopausal women. Secondary objectives are to…

The effect of hormonal replacement therapy on menopausal complaints related to biochemical changes in surgically and naturally postmenopausal women.
A prospective observational comparative study.

The aims of this prospective study are to investigate:1a: Changes in menopausal symptoms and biochemical changes as result of PBSO in premenopausal women.1b: Changes in menopausal symptoms and biochemical changes as result of PBSO in postmenopausal…

Effectiveness of saline-infused sonography and hysteroscopy in the work-up for postmenopausal bleeding

SIS and hysteroscopy in the work-up for postmenopausal bleeding will be studied. Cost en medical effectiveness in terms of treatment of the postmenopausal bleeding will be evaluated. To assess which women need saline-infused sonography and/or…

Cardiovascular risk after risk-reducing salpingo-oophorectomy in BRCA1/2 mutation carriers: CARSOBRA study

Primary objectiveIs RRSO at age <= 45 in BRCA1/2 mutation carriers a risk factor for development of subclinical atherosclerosis, independent of traditional cardiovascular risk factors? Secondary objectiveAre menopausal symptoms in BRCA1/2…

Non-invasive measurement of vaginal tissue hydration in women with and without GSM

The primary objective is to evaluate the reproducibility of the Corneometer® as a measurement instrument to quantify hydration of the vaginal wall, evaluated by intra- and interobserver variability. The secondary objective is to measure the response…